Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus.

Détails

ID Serval
serval:BIB_2DC475008819
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus.
Périodique
Nature
Auteur(s)
Froguel P., Vaxillaire M., Sun F., Velho G., Zouali H., Butel M.O., Lesage S., Vionnet N., Clément K., Fougerousse F., Tanizawa Y., Weissenbach J., Beckmann J.S., Lathrop G.M., Passa P., Permutt M.A., Cohen D.
ISSN
0028-0836
Statut éditorial
Publié
Date de publication
03/1992
Peer-reviewed
Oui
Volume
356
Numéro
6365
Pages
162-164
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. - Publication Status: ppublish
Résumé
Non-insulin-dependent diabetes mellitus (NIDDM) is a major health problem, affecting 5% of the world population. Genetic factors are important in NIDDM, but the mechanisms leading to glucose intolerance are unknown. Genetic linkage has been investigated in multigeneration families to localize, and ultimately identify, the gene(s) predisposing to NIDDM. Here we report linkage between the glucokinase locus on chromosome 7p and diabetes in 16 French families with maturity-onset diabetes of the young, a form of NIDDM characterized by monogenic autosomal dominant transmission and early age of onset. Statistical evidence of genetic heterogeneity was significant, with an estimated 45-95% of the 16 families showing linkage to glucokinase. Because glucokinase is a key enzyme of blood glucose homeostasis, these results are evidence that a gene involved in glucose metabolism could be implicated in the pathogenesis of NIDDM.
Mots-clé
Adenosine Deaminase/genetics, Base Sequence, Blood Glucose/metabolism, Chromosomes, Human, Pair 7, DNA/chemistry, Diabetes Mellitus, Type 2/enzymology, Diabetes Mellitus, Type 2/genetics, Glucokinase/genetics, Humans, Linkage (Genetics), Lod Score, Molecular Sequence Data, Monosaccharide Transport Proteins/genetics, Mutation, Pedigree, Polymerase Chain Reaction
Pubmed
Web of science
Création de la notice
25/01/2008 17:18
Dernière modification de la notice
20/08/2019 14:12
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