Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus.

Details

Serval ID
serval:BIB_2DC475008819
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus.
Journal
Nature
Author(s)
Froguel P., Vaxillaire M., Sun F., Velho G., Zouali H., Butel M.O., Lesage S., Vionnet N., Clément K., Fougerousse F., Tanizawa Y., Weissenbach J., Beckmann J.S., Lathrop G.M., Passa P., Permutt M.A., Cohen D.
ISSN
0028-0836
Publication state
Published
Issued date
03/1992
Peer-reviewed
Oui
Volume
356
Number
6365
Pages
162-164
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. - Publication Status: ppublish
Abstract
Non-insulin-dependent diabetes mellitus (NIDDM) is a major health problem, affecting 5% of the world population. Genetic factors are important in NIDDM, but the mechanisms leading to glucose intolerance are unknown. Genetic linkage has been investigated in multigeneration families to localize, and ultimately identify, the gene(s) predisposing to NIDDM. Here we report linkage between the glucokinase locus on chromosome 7p and diabetes in 16 French families with maturity-onset diabetes of the young, a form of NIDDM characterized by monogenic autosomal dominant transmission and early age of onset. Statistical evidence of genetic heterogeneity was significant, with an estimated 45-95% of the 16 families showing linkage to glucokinase. Because glucokinase is a key enzyme of blood glucose homeostasis, these results are evidence that a gene involved in glucose metabolism could be implicated in the pathogenesis of NIDDM.
Keywords
Adenosine Deaminase/genetics, Base Sequence, Blood Glucose/metabolism, Chromosomes, Human, Pair 7, DNA/chemistry, Diabetes Mellitus, Type 2/enzymology, Diabetes Mellitus, Type 2/genetics, Glucokinase/genetics, Humans, Linkage (Genetics), Lod Score, Molecular Sequence Data, Monosaccharide Transport Proteins/genetics, Mutation, Pedigree, Polymerase Chain Reaction
Pubmed
Web of science
Create date
25/01/2008 16:18
Last modification date
20/08/2019 13:12
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