Granzyme A-immunoreactive cells in synovial fluid in reactive and rheumatoid arthritis

Détails

ID Serval
serval:BIB_2D69B7C31CA8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Granzyme A-immunoreactive cells in synovial fluid in reactive and rheumatoid arthritis
Périodique
Clinical Rheumatology
Auteur(s)
Nordstrom  D. C., Konttinen  Y. T., Sorsa  T., Nykanen  P., Pettersson  T., Santavirta  S., Tschopp  J.
ISSN
0770-3198 (Print)
Statut éditorial
Publié
Date de publication
12/1992
Volume
11
Numéro
4
Pages
529-32
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Dec
Résumé
Perforin and granzyme A co-localize in the cytotoxic granules of killer cells like cytotoxic T lymphocytes (CTL). Perforin is the cytolytic pore-forming protein, whereas the function of the homodimeric serine protease granzyme A and other members of the granzyme family is still unclear. Granzyme A-immunoreactive cells formed 8 +/- 2% of the resting peripheral blood lymphocytes of healthy individuals. In contrast, granzyme A-positive cells formed 15% of peripheral blood mononuclear cells in patients with reactive or rheumatoid arthritis. However, 29 +/- 4% (p < 0.05 compared to normal peripheral blood) and 25 +/- 4% (p < 0.05) of all lymphocytes in synovial fluid in reactive and rheumatoid arthritis, respectively, were granzyme A-positive. This suggests involvement of cell-mediated cytolytic mechanisms in the articular pathogenic mechanisms. This involvement, however, does not differentiate between reactive and rheumatoid arthritis.
Mots-clé
Adult Aged Arthritis, Reactive/blood/*enzymology/pathology Female Granzymes Humans Immunohistochemistry/methods Male Middle Aged Serine Endopeptidases/blood/*metabolism Staining and Labeling Synovial Fluid/cytology/*enzymology
Pubmed
Web of science
Création de la notice
24/01/2008 15:18
Dernière modification de la notice
20/08/2019 13:12
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