Granzyme A-immunoreactive cells in synovial fluid in reactive and rheumatoid arthritis
Details
Serval ID
serval:BIB_2D69B7C31CA8
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Granzyme A-immunoreactive cells in synovial fluid in reactive and rheumatoid arthritis
Journal
Clinical Rheumatology
ISSN
0770-3198 (Print)
Publication state
Published
Issued date
12/1992
Volume
11
Number
4
Pages
529-32
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Dec
Research Support, Non-U.S. Gov't --- Old month value: Dec
Abstract
Perforin and granzyme A co-localize in the cytotoxic granules of killer cells like cytotoxic T lymphocytes (CTL). Perforin is the cytolytic pore-forming protein, whereas the function of the homodimeric serine protease granzyme A and other members of the granzyme family is still unclear. Granzyme A-immunoreactive cells formed 8 +/- 2% of the resting peripheral blood lymphocytes of healthy individuals. In contrast, granzyme A-positive cells formed 15% of peripheral blood mononuclear cells in patients with reactive or rheumatoid arthritis. However, 29 +/- 4% (p < 0.05 compared to normal peripheral blood) and 25 +/- 4% (p < 0.05) of all lymphocytes in synovial fluid in reactive and rheumatoid arthritis, respectively, were granzyme A-positive. This suggests involvement of cell-mediated cytolytic mechanisms in the articular pathogenic mechanisms. This involvement, however, does not differentiate between reactive and rheumatoid arthritis.
Keywords
Adult
Aged
Arthritis, Reactive/blood/*enzymology/pathology
Female
Granzymes
Humans
Immunohistochemistry/methods
Male
Middle Aged
Serine Endopeptidases/blood/*metabolism
Staining and Labeling
Synovial Fluid/cytology/*enzymology
Pubmed
Web of science
Create date
24/01/2008 15:18
Last modification date
20/08/2019 13:12