Cellular pathology of mitral valve prolapse.

Détails

ID Serval
serval:BIB_2D13F35EAB9E
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Cellular pathology of mitral valve prolapse.
Périodique
Cardiovascular Pathology
Auteur⸱e⸱s
Prunotto M., Caimmi P.P., Bongiovanni M.
ISSN
1879-1336 (Electronic)
ISSN-L
1054-8807
Statut éditorial
Publié
Date de publication
2010
Volume
19
Numéro
4
Pages
e113-e117
Langue
anglais
Notes
Publication types: Journal Article ; ReviewPublication Status: ppublish
Résumé
BACKGROUND: Mitral valve prolapse (MVP) is the most frequent cause of chronic, pure, and isolated mitral regurgitation, and is estimated to affect more than 144 million individuals worldwide. This short review focuses in particular on the structural and cellular aspects of MVP in humans. The key microscopic change in MVP appears to occur in the fibrosa, on which the structural integrity of the entire valve depends. Recent discoveries showed that proteoglycans may play an active role in both MVP initiation and/or progression together with valvular interstitial cells. A full understanding of the cellular basis of MVP goes beyond a mere mechanicistic description of the disease, involving the transformation of resting fibroblasts into activated myofibroblasts.
CONCLUSIONS: Mitral valve could represent therefore an ideal environment to study early transformation phases of fibroblasts toward a protomyofibroblast phenotype.
Mots-clé
Cell Differentiation, Fibroblasts/cytology, Humans, Mitral Valve/metabolism, Mitral Valve/pathology, Mitral Valve Prolapse/pathology, Proteoglycans/metabolism
Pubmed
Création de la notice
05/02/2015 11:03
Dernière modification de la notice
20/08/2019 13:12
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