Cellular pathology of mitral valve prolapse.

Details

Serval ID
serval:BIB_2D13F35EAB9E
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Cellular pathology of mitral valve prolapse.
Journal
Cardiovascular Pathology
Author(s)
Prunotto M., Caimmi P.P., Bongiovanni M.
ISSN
1879-1336 (Electronic)
ISSN-L
1054-8807
Publication state
Published
Issued date
2010
Volume
19
Number
4
Pages
e113-e117
Language
english
Notes
Publication types: Journal Article ; ReviewPublication Status: ppublish
Abstract
BACKGROUND: Mitral valve prolapse (MVP) is the most frequent cause of chronic, pure, and isolated mitral regurgitation, and is estimated to affect more than 144 million individuals worldwide. This short review focuses in particular on the structural and cellular aspects of MVP in humans. The key microscopic change in MVP appears to occur in the fibrosa, on which the structural integrity of the entire valve depends. Recent discoveries showed that proteoglycans may play an active role in both MVP initiation and/or progression together with valvular interstitial cells. A full understanding of the cellular basis of MVP goes beyond a mere mechanicistic description of the disease, involving the transformation of resting fibroblasts into activated myofibroblasts.
CONCLUSIONS: Mitral valve could represent therefore an ideal environment to study early transformation phases of fibroblasts toward a protomyofibroblast phenotype.
Keywords
Cell Differentiation, Fibroblasts/cytology, Humans, Mitral Valve/metabolism, Mitral Valve/pathology, Mitral Valve Prolapse/pathology, Proteoglycans/metabolism
Pubmed
Create date
05/02/2015 11:03
Last modification date
20/08/2019 13:12
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