Usefulness of Mendelian randomization in observational epidemiology.

Détails

Ressource 1Télécharger: BIB_2B7F79FEEAB8.P001.pdf (425.08 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_2B7F79FEEAB8
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Usefulness of Mendelian randomization in observational epidemiology.
Périodique
International Journal of Environmental Research and Public Health
Auteur(s)
Bochud M., Rousson V.
ISSN
1661-7827
Statut éditorial
Publié
Date de publication
2010
Peer-reviewed
Oui
Volume
7
Numéro
3
Pages
711-728
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
Mendelian randomization refers to the random allocation of alleles at the time of gamete formation. In observational epidemiology, this refers to the use of genetic variants to estimate a causal effect between a modifiable risk factor and an outcome of interest. In this review, we recall the principles of a "Mendelian randomization" approach in observational epidemiology, which is based on the technique of instrumental variables; we provide simulations and an example based on real data to demonstrate its implications; we present the results of a systematic search on original articles having used this approach; and we discuss some limitations of this approach in view of what has been found so far.
Mots-clé
Alleles, Epidemiologic Studies, Genetic Predisposition to Disease, Humans, Risk Factors
Pubmed
Web of science
Open Access
Oui
Création de la notice
19/01/2011 11:45
Dernière modification de la notice
20/08/2019 13:10
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