Usefulness of Mendelian randomization in observational epidemiology.

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State: Public
Version: Final published version
Serval ID
serval:BIB_2B7F79FEEAB8
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Usefulness of Mendelian randomization in observational epidemiology.
Journal
International Journal of Environmental Research and Public Health
Author(s)
Bochud M., Rousson V.
ISSN
1661-7827
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
7
Number
3
Pages
711-728
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
Mendelian randomization refers to the random allocation of alleles at the time of gamete formation. In observational epidemiology, this refers to the use of genetic variants to estimate a causal effect between a modifiable risk factor and an outcome of interest. In this review, we recall the principles of a "Mendelian randomization" approach in observational epidemiology, which is based on the technique of instrumental variables; we provide simulations and an example based on real data to demonstrate its implications; we present the results of a systematic search on original articles having used this approach; and we discuss some limitations of this approach in view of what has been found so far.
Keywords
Alleles, Epidemiologic Studies, Genetic Predisposition to Disease, Humans, Risk Factors
Pubmed
Web of science
Open Access
Yes
Create date
19/01/2011 11:45
Last modification date
20/08/2019 13:10
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