Hypocretinergic interactions with the serotonergic system regulate REM sleep and cataplexy.

Détails

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Etat: Public
Version: de l'auteur
Licence: CC BY 4.0
ID Serval
serval:BIB_2A90B8BA3A06
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Hypocretinergic interactions with the serotonergic system regulate REM sleep and cataplexy.
Périodique
Nature communications
Auteur(s)
Seifinejad A., Li S., Possovre M.L., Vassalli A., Tafti M.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Statut éditorial
Publié
Date de publication
27/11/2020
Peer-reviewed
Oui
Volume
11
Numéro
1
Pages
6034
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Résumé
Loss of muscle tone triggered by emotions is called cataplexy and is the pathognomonic symptom of narcolepsy, which is caused by hypocretin deficiency. Cataplexy is classically considered to be an abnormal manifestation of REM sleep and is treated by selective serotonin (5HT) reuptake inhibitors. Here we show that deleting the 5HT transporter in hypocretin knockout mice suppressed cataplexy while dramatically increasing REM sleep. Additionally, double knockout mice showed a significant deficit in the buildup of sleep need. Deleting one allele of the 5HT transporter in hypocretin knockout mice strongly increased EEG theta power during REM sleep and theta and gamma powers during wakefulness. Deleting hypocretin receptors in the dorsal raphe neurons of adult mice did not induce cataplexy but consolidated REM sleep. Our results indicate that cataplexy and REM sleep are regulated by different mechanisms and both states and sleep need are regulated by the hypocretinergic input into 5HT neurons.
Mots-clé
Animals, Cataplexy/genetics, Cataplexy/physiopathology, Electroencephalography, Electromyography, Genotype, Mice, Knockout, Orexins/genetics, Orexins/metabolism, Serotonin/genetics, Serotonin/metabolism, Sleep, REM/physiology, Theta Rhythm/physiology, Time Factors, Wakefulness/physiology
Pubmed
Web of science
Open Access
Oui
Création de la notice
07/12/2020 16:09
Dernière modification de la notice
08/07/2021 6:36
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