Hypocretinergic interactions with the serotonergic system regulate REM sleep and cataplexy.

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State: Public
Version: author
License: CC BY 4.0
Serval ID
serval:BIB_2A90B8BA3A06
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Hypocretinergic interactions with the serotonergic system regulate REM sleep and cataplexy.
Journal
Nature communications
Author(s)
Seifinejad A., Li S., Possovre M.L., Vassalli A., Tafti M.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Publication state
Published
Issued date
27/11/2020
Peer-reviewed
Oui
Volume
11
Number
1
Pages
6034
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Loss of muscle tone triggered by emotions is called cataplexy and is the pathognomonic symptom of narcolepsy, which is caused by hypocretin deficiency. Cataplexy is classically considered to be an abnormal manifestation of REM sleep and is treated by selective serotonin (5HT) reuptake inhibitors. Here we show that deleting the 5HT transporter in hypocretin knockout mice suppressed cataplexy while dramatically increasing REM sleep. Additionally, double knockout mice showed a significant deficit in the buildup of sleep need. Deleting one allele of the 5HT transporter in hypocretin knockout mice strongly increased EEG theta power during REM sleep and theta and gamma powers during wakefulness. Deleting hypocretin receptors in the dorsal raphe neurons of adult mice did not induce cataplexy but consolidated REM sleep. Our results indicate that cataplexy and REM sleep are regulated by different mechanisms and both states and sleep need are regulated by the hypocretinergic input into 5HT neurons.
Keywords
Animals, Cataplexy/genetics, Cataplexy/physiopathology, Electroencephalography, Electromyography, Genotype, Mice, Knockout, Orexins/genetics, Orexins/metabolism, Serotonin/genetics, Serotonin/metabolism, Sleep, REM/physiology, Theta Rhythm/physiology, Time Factors, Wakefulness/physiology
Pubmed
Web of science
Open Access
Yes
Create date
07/12/2020 16:09
Last modification date
08/07/2021 6:36
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