Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson's Disease.

Détails

ID Serval
serval:BIB_2A2AC66FC17A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson's Disease.
Périodique
Plos One
Auteur(s)
Oueslati A., Lovisa B., Perrin J., Wagnières G., van den Bergh H., Tardy Y., Lashuel H.A.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Statut éditorial
Publié
Date de publication
10/2015
Volume
10
Numéro
10
Pages
e0140880
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Résumé
Converging lines of evidence indicate that near-infrared light treatment, also known as photobiomodulation (PBM), may exert beneficial effects and protect against cellular toxicity and degeneration in several animal models of human pathologies, including neurodegenerative disorders. In the present study, we report that chronic PMB treatment mitigates dopaminergic loss induced by unilateral overexpression of human α-synuclein (α-syn) in the substantia nigra of an AAV-based rat genetic model of Parkinson's disease (PD). In this model, daily exposure of both sides of the rat's head to 808-nm near-infrared light for 28 consecutive days alleviated α-syn-induced motor impairment, as assessed using the cylinder test. This treatment also significantly reduced dopaminergic neuronal loss in the injected substantia nigra and preserved dopaminergic fibers in the ipsilateral striatum. These beneficial effects were sustained for at least 6 weeks after discontinuing the treatment. Together, our data point to PBM as a possible therapeutic strategy for the treatment of PD and other related synucleinopathies.
Mots-clé
Animals, Corpus Striatum/metabolism, Corpus Striatum/pathology, Disease Models, Animal, Dopaminergic Neurons/metabolism, Dopaminergic Neurons/pathology, Female, Low-Level Light Therapy, Parkinson Disease/genetics, Parkinson Disease/metabolism, Rats, Rats, Sprague-Dawley, Substantia Nigra/metabolism, Substantia Nigra/pathology
Pubmed
Web of science
Open Access
Oui
Création de la notice
30/08/2016 7:25
Dernière modification de la notice
28/01/2020 6:26
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