Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson's Disease.

Details

Serval ID
serval:BIB_2A2AC66FC17A
Type
Article: article from journal or magazin.
Collection
Publications
Title
Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson's Disease.
Journal
Plos One
Author(s)
Oueslati A., Lovisa B., Perrin J., Wagnières G., van den Bergh H., Tardy Y., Lashuel H.A.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Publication state
Published
Issued date
10/2015
Volume
10
Number
10
Pages
e0140880
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Converging lines of evidence indicate that near-infrared light treatment, also known as photobiomodulation (PBM), may exert beneficial effects and protect against cellular toxicity and degeneration in several animal models of human pathologies, including neurodegenerative disorders. In the present study, we report that chronic PMB treatment mitigates dopaminergic loss induced by unilateral overexpression of human α-synuclein (α-syn) in the substantia nigra of an AAV-based rat genetic model of Parkinson's disease (PD). In this model, daily exposure of both sides of the rat's head to 808-nm near-infrared light for 28 consecutive days alleviated α-syn-induced motor impairment, as assessed using the cylinder test. This treatment also significantly reduced dopaminergic neuronal loss in the injected substantia nigra and preserved dopaminergic fibers in the ipsilateral striatum. These beneficial effects were sustained for at least 6 weeks after discontinuing the treatment. Together, our data point to PBM as a possible therapeutic strategy for the treatment of PD and other related synucleinopathies.
Keywords
Animals, Corpus Striatum/metabolism, Corpus Striatum/pathology, Disease Models, Animal, Dopaminergic Neurons/metabolism, Dopaminergic Neurons/pathology, Female, Low-Level Light Therapy, Parkinson Disease/genetics, Parkinson Disease/metabolism, Rats, Rats, Sprague-Dawley, Substantia Nigra/metabolism, Substantia Nigra/pathology
Pubmed
Web of science
Open Access
Yes
Create date
30/08/2016 7:25
Last modification date
28/01/2020 6:26
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