Circadian hepatocyte clocks keep synchrony in the absence of a master pacemaker in the suprachiasmatic nucleus or other extrahepatic clocks.

Détails

ID Serval
serval:BIB_2838A72DA401
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Circadian hepatocyte clocks keep synchrony in the absence of a master pacemaker in the suprachiasmatic nucleus or other extrahepatic clocks.
Périodique
Genes & development
Auteur⸱e⸱s
Sinturel F., Gos P., Petrenko V., Hagedorn C., Kreppel F., Storch K.F., Knutti D., Liani A., Weitz C., Emmenegger Y., Franken P., Bonacina L., Dibner C., Schibler U.
ISSN
1549-5477 (Electronic)
ISSN-L
0890-9369
Statut éditorial
Publié
Date de publication
01/03/2021
Peer-reviewed
Oui
Volume
35
Numéro
5-6
Pages
329-334
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
It has been assumed that the suprachiasmatic nucleus (SCN) synchronizes peripheral circadian oscillators. However, this has never been convincingly shown, since biochemical time series experiments are not feasible in behaviorally arrhythmic animals. By using long-term bioluminescence recording in freely moving mice, we show that the SCN is indeed required for maintaining synchrony between organs. Surprisingly, however, circadian oscillations persist in the livers of mice devoid of an SCN or oscillators in cells other than hepatocytes. Hence, similar to SCN neurons, hepatocytes can maintain phase coherence in the absence of Zeitgeber signals produced by other organs or environmental cycles.
Mots-clé
circadian gene expression, in vivo bioluminescence recording, liver, suprachiasmatic nucleus
Pubmed
Web of science
Open Access
Oui
Création de la notice
01/03/2021 14:32
Dernière modification de la notice
27/03/2021 7:32
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