Circadian hepatocyte clocks keep synchrony in the absence of a master pacemaker in the suprachiasmatic nucleus or other extrahepatic clocks.

Details

Serval ID
serval:BIB_2838A72DA401
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Circadian hepatocyte clocks keep synchrony in the absence of a master pacemaker in the suprachiasmatic nucleus or other extrahepatic clocks.
Journal
Genes & development
Author(s)
Sinturel F., Gos P., Petrenko V., Hagedorn C., Kreppel F., Storch K.F., Knutti D., Liani A., Weitz C., Emmenegger Y., Franken P., Bonacina L., Dibner C., Schibler U.
ISSN
1549-5477 (Electronic)
ISSN-L
0890-9369
Publication state
Published
Issued date
01/03/2021
Peer-reviewed
Oui
Volume
35
Number
5-6
Pages
329-334
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
It has been assumed that the suprachiasmatic nucleus (SCN) synchronizes peripheral circadian oscillators. However, this has never been convincingly shown, since biochemical time series experiments are not feasible in behaviorally arrhythmic animals. By using long-term bioluminescence recording in freely moving mice, we show that the SCN is indeed required for maintaining synchrony between organs. Surprisingly, however, circadian oscillations persist in the livers of mice devoid of an SCN or oscillators in cells other than hepatocytes. Hence, similar to SCN neurons, hepatocytes can maintain phase coherence in the absence of Zeitgeber signals produced by other organs or environmental cycles.
Keywords
circadian gene expression, in vivo bioluminescence recording, liver, suprachiasmatic nucleus
Pubmed
Web of science
Open Access
Yes
Create date
01/03/2021 14:32
Last modification date
27/03/2021 7:32
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