Genetic advances in dermatophytes
Détails
Etat: Public
Version: Final published version
Licence: Non spécifiée
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
ID Serval
serval:BIB_277FA1634FCC
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Genetic advances in dermatophytes
Périodique
Fems Microbiology Letters
ISSN
1574-6968 (Electronic)
ISSN-L
0378-1097
Statut éditorial
Publié
Date de publication
2011
Volume
320
Numéro
2
Pages
79-86
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
Millions of superficial fungal infections are annually observed in humans and animals. The majority of these mycoses are caused by dermatophytes, a specialized group of filamentous fungi that exclusively infect keratinized host structures. Despite the high prevalence of the disease, dermatophytosis, little is known about the pathogenicity mechanisms of these microorganisms. This drawback may be related to the fact that dermatophytes have been investigated poorly at the molecular level. In contrast to many other pathogenic fungi, they grow comparatively slowly under in vitro conditions, and in the last decades, only a limited number of molecular tools have been established for their manipulation. In recent years, however, major promising approaches were undertaken to improve genetic analyses in dermatophytes. These strategies include efficient systems for targeted gene inactivation and gene silencing, and broad transcriptional profiling techniques, which have even been applied in sophisticated infection models. As a fundamental prerequisite for future genetic analyses, full genome sequences of seven different dermatophyte species have become available recently. Therefore, it appeared timely to review the available molecular tools and methodologies in dermatophyte research, which may provide future insights into the virulence of these clinically important pathogens.
Mots-clé
Arthrodermataceae/genetics, Dermatomycoses/microbiology, Trichophyton/genetics
Pubmed
Web of science
Open Access
Oui
Création de la notice
13/07/2018 10:00
Dernière modification de la notice
14/02/2022 8:54