Genetic advances in dermatophytes

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Serval ID
serval:BIB_277FA1634FCC
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Genetic advances in dermatophytes
Journal
Fems Microbiology Letters
Author(s)
Grumbt M., Monod M., Staib P.
ISSN
1574-6968 (Electronic)
ISSN-L
0378-1097
Publication state
Published
Issued date
2011
Volume
320
Number
2
Pages
79-86
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Millions of superficial fungal infections are annually observed in humans and animals. The majority of these mycoses are caused by dermatophytes, a specialized group of filamentous fungi that exclusively infect keratinized host structures. Despite the high prevalence of the disease, dermatophytosis, little is known about the pathogenicity mechanisms of these microorganisms. This drawback may be related to the fact that dermatophytes have been investigated poorly at the molecular level. In contrast to many other pathogenic fungi, they grow comparatively slowly under in vitro conditions, and in the last decades, only a limited number of molecular tools have been established for their manipulation. In recent years, however, major promising approaches were undertaken to improve genetic analyses in dermatophytes. These strategies include efficient systems for targeted gene inactivation and gene silencing, and broad transcriptional profiling techniques, which have even been applied in sophisticated infection models. As a fundamental prerequisite for future genetic analyses, full genome sequences of seven different dermatophyte species have become available recently. Therefore, it appeared timely to review the available molecular tools and methodologies in dermatophyte research, which may provide future insights into the virulence of these clinically important pathogens.
Keywords
Arthrodermataceae/genetics, Dermatomycoses/microbiology, Trichophyton/genetics
Pubmed
Web of science
Open Access
Yes
Create date
13/07/2018 10:00
Last modification date
16/02/2021 7:27
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