Peripheral administration of lactate produces antidepressant-like effects.

Détails

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Etat: Public
Version: Final published version
ID Serval
serval:BIB_26DA16FC7ECA
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Peripheral administration of lactate produces antidepressant-like effects.
Périodique
Molecular psychiatry
Auteur(s)
Carrard A., Elsayed M., Margineanu M., Boury-Jamot B., Fragnière L., Meylan E.M., Petit J.M., Fiumelli H., Magistretti P.J., Martin J.L.
ISSN
1476-5578 (Electronic)
ISSN-L
1359-4184
Statut éditorial
Publié
Date de publication
02/2018
Peer-reviewed
Oui
Volume
23
Numéro
2
Pages
392-399
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
In addition to its role as metabolic substrate that can sustain neuronal function and viability, emerging evidence supports a role for l-lactate as an intercellular signaling molecule involved in synaptic plasticity. Clinical and basic research studies have shown that major depression and chronic stress are associated with alterations in structural and functional plasticity. These findings led us to investigate the role of l-lactate as a potential novel antidepressant. Here we show that peripheral administration of l-lactate produces antidepressant-like effects in different animal models of depression that respond to acute and chronic antidepressant treatment. The antidepressant-like effects of l-lactate are associated with increases in hippocampal lactate levels and with changes in the expression of target genes involved in serotonin receptor trafficking, astrocyte functions, neurogenesis, nitric oxide synthesis and cAMP signaling. Further elucidation of the mechanisms underlying the antidepressant effects of l-lactate may help to identify novel therapeutic targets for the treatment of depression.
Mots-clé
Animals, Antidepressive Agents/pharmacology, Astrocytes, Depression/drug therapy, Depressive Disorder, Major/drug therapy, Disease Models, Animal, Hippocampus/metabolism, Lactic Acid/administration & dosage, Lactic Acid/pharmacology, Male, Mice, Mice, Inbred C57BL, Neurogenesis/drug effects, Neuronal Plasticity/drug effects, Neurons, Signal Transduction/drug effects
Pubmed
Web of science
Open Access
Oui
Création de la notice
27/06/2017 9:21
Dernière modification de la notice
09/09/2019 5:26
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