Peripheral administration of lactate produces antidepressant-like effects.

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Version: Final published version
Serval ID
serval:BIB_26DA16FC7ECA
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Peripheral administration of lactate produces antidepressant-like effects.
Journal
Molecular psychiatry
Author(s)
Carrard A., Elsayed M., Margineanu M., Boury-Jamot B., Fragnière L., Meylan E.M., Petit J.M., Fiumelli H., Magistretti P.J., Martin J.L.
ISSN
1476-5578 (Electronic)
ISSN-L
1359-4184
Publication state
Published
Issued date
02/2018
Peer-reviewed
Oui
Volume
23
Number
2
Pages
392-399
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
In addition to its role as metabolic substrate that can sustain neuronal function and viability, emerging evidence supports a role for l-lactate as an intercellular signaling molecule involved in synaptic plasticity. Clinical and basic research studies have shown that major depression and chronic stress are associated with alterations in structural and functional plasticity. These findings led us to investigate the role of l-lactate as a potential novel antidepressant. Here we show that peripheral administration of l-lactate produces antidepressant-like effects in different animal models of depression that respond to acute and chronic antidepressant treatment. The antidepressant-like effects of l-lactate are associated with increases in hippocampal lactate levels and with changes in the expression of target genes involved in serotonin receptor trafficking, astrocyte functions, neurogenesis, nitric oxide synthesis and cAMP signaling. Further elucidation of the mechanisms underlying the antidepressant effects of l-lactate may help to identify novel therapeutic targets for the treatment of depression.
Keywords
Animals, Antidepressive Agents/pharmacology, Astrocytes, Depression/drug therapy, Depressive Disorder, Major/drug therapy, Disease Models, Animal, Hippocampus/metabolism, Lactic Acid/administration & dosage, Lactic Acid/pharmacology, Male, Mice, Mice, Inbred C57BL, Neurogenesis/drug effects, Neuronal Plasticity/drug effects, Neurons, Signal Transduction/drug effects
Pubmed
Web of science
Open Access
Yes
Create date
27/06/2017 9:21
Last modification date
09/09/2019 5:26
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