Confirmation of functional zones within the human subthalamic nucleus: patterns of connectivity and sub-parcellation using diffusion weighted imaging.
Détails
Etat: Public
Version: Final published version
ID Serval
serval:BIB_265D06B98C95
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Confirmation of functional zones within the human subthalamic nucleus: patterns of connectivity and sub-parcellation using diffusion weighted imaging.
Périodique
Neuroimage
ISSN
1095-9572 (Electronic)
ISSN-L
1053-8119
Statut éditorial
Publié
Date de publication
2012
Volume
60
Numéro
1
Pages
83-94
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
The subthalamic nucleus (STN) is a small, glutamatergic nucleus situated in the diencephalon. A critical component of normal motor function, it has become a key target for deep brain stimulation in the treatment of Parkinson's disease. Animal studies have demonstrated the existence of three functional sub-zones but these have never been shown conclusively in humans. In this work, a data driven method with diffusion weighted imaging demonstrated that three distinct clusters exist within the human STN based on brain connectivity profiles. The STN was successfully sub-parcellated into these regions, demonstrating good correspondence with that described in the animal literature. The local connectivity of each sub-region supported the hypothesis of bilateral limbic, associative and motor regions occupying the anterior, mid and posterior portions of the nucleus respectively. This study is the first to achieve in-vivo, non-invasive anatomical parcellation of the human STN into three anatomical zones within normal diagnostic scan times, which has important future implications for deep brain stimulation surgery.
Mots-clé
Adult, Brain Mapping, Diffusion Magnetic Resonance Imaging, Diffusion Tensor Imaging, Female, Humans, Male, Review Literature as Topic, Subthalamic Nucleus/anatomy & histology, Subthalamic Nucleus/physiology
Pubmed
Web of science
Open Access
Oui
Création de la notice
05/03/2012 20:07
Dernière modification de la notice
20/08/2019 14:05