Stroke damage in mice after knocking the neutrophin-4 gene into the brain-derived neurotrophic factor locus

Détails

ID Serval
serval:BIB_26061C0858A6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Stroke damage in mice after knocking the neutrophin-4 gene into the brain-derived neurotrophic factor locus
Périodique
Journal of Cerebral Blood Flow and Metabolism
Auteur(s)
Endres  M., Fan  G., Hirt  L., Jaenisch  R.
ISSN
0271-678X (Print)
Statut éditorial
Publié
Date de publication
02/2003
Peer-reviewed
Oui
Volume
23
Numéro
2
Pages
150-3
Notes
Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. --- Old month value: Feb
Résumé
Neurotrophins play a protective role during cerebral ischemia, and mice lacking both alleles for neurotrophin 4 (Nt4-/- ) or deficient in a single allele for brain-derived neurotrophic factor (Bdnf+/-) have increased susceptibility to cerebral ischemia. This study directly compared the biologic activities of brain-derived neurotrophic factor (BDNF) and NT4 by replacing the coding sequence with the Nt4 sequence (Bdnf +/nt4-ki ). Mice expressing one allele in place of develop 61% bigger lesions after 1-hour middle cerebral artery occlusion compared with wild-type littermates. Physiologic parameters did not contribute to ischemia susceptibility. In conclusion, NT4 is less potent than BDNF in promoting brain survival after stroke.
Mots-clé
Animals Brain Ischemia/complications/metabolism/pathology Brain-Derived Neurotrophic Factor/genetics/*metabolism Cerebral Infarction/pathology Cerebrovascular Accident/complications/*metabolism/*pathology Mice Mice, Transgenic/genetics Nerve Growth Factors/genetics/*metabolism Nervous System Diseases/etiology
Pubmed
Web of science
Création de la notice
25/01/2008 13:40
Dernière modification de la notice
20/08/2019 14:04
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