Article: article from journal or magazin.
Stroke damage in mice after knocking the neutrophin-4 gene into the brain-derived neurotrophic factor locus
Journal of Cerebral Blood Flow and Metabolism
Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. --- Old month value: Feb
Neurotrophins play a protective role during cerebral ischemia, and mice lacking both alleles for neurotrophin 4 (Nt4-/- ) or deficient in a single allele for brain-derived neurotrophic factor (Bdnf+/-) have increased susceptibility to cerebral ischemia. This study directly compared the biologic activities of brain-derived neurotrophic factor (BDNF) and NT4 by replacing the coding sequence with the Nt4 sequence (Bdnf +/nt4-ki ). Mice expressing one allele in place of develop 61% bigger lesions after 1-hour middle cerebral artery occlusion compared with wild-type littermates. Physiologic parameters did not contribute to ischemia susceptibility. In conclusion, NT4 is less potent than BDNF in promoting brain survival after stroke.
Animals Brain Ischemia/complications/metabolism/pathology Brain-Derived Neurotrophic Factor/genetics/*metabolism Cerebral Infarction/pathology Cerebrovascular Accident/complications/*metabolism/*pathology Mice Mice, Transgenic/genetics Nerve Growth Factors/genetics/*metabolism Nervous System Diseases/etiology
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