Virus burden in lymph nodes and blood of subjects with primary human immunodeficiency virus type 1 infection on bitherapy
Détails
Etat: Public
Version: Final published version
Licence: Non spécifiée
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
ID Serval
serval:BIB_24FEFC536E15
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Virus burden in lymph nodes and blood of subjects with primary human immunodeficiency virus type 1 infection on bitherapy
Périodique
Journal of Infectious Diseases
ISSN
0022-1899 (Print)
Statut éditorial
Publié
Date de publication
06/1998
Volume
177
Numéro
6
Pages
1497-501
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jun
Research Support, Non-U.S. Gov't --- Old month value: Jun
Résumé
At present, it is not known whether undetectable plasma viremia corresponds to an absence of human immunodeficiency virus type 1 (HIV-1) replication in lymphoid tissues. This issue has been explored in 11 subjects with primary HIV-1 infection treated with zidovudine plus didanosine by evaluating virologic markers in blood and lymphoid tissues 9-18 months after initiation of treatment. These markers include plasma viremia, measured with a sensitive assay with a detection limit of 20 HIV-1 RNA copies/mL, infectious virus titers and proviral DNA in lymph node mononuclear cells, and HIV-1 RNA in lymphoid tissue. Five subjects had plasma viremia <20 copies/mL and showed no evidence of viral replication in lymphoid tissue. Six subjects had both detectable plasma viremia and evidence of HIV-1 RNA in lymphoid tissue. The results indicate that absence of detectable HIV RNA in lymphoid tissue is associated with viremia levels of HIV-1 RNA <20 copies/mL.
Mots-clé
Adenoids/pathology/virology
Adult
Anti-HIV Agents/*therapeutic use
CD4-CD8 Ratio
DNA, Viral/analysis
Dendritic Cells/virology
Didanosine/*therapeutic use
Drug Therapy, Combination
Female
HIV Infections/*drug therapy/pathology/*virology
HIV-1/genetics/*physiology
Humans
Lymph Nodes/pathology/*virology
Male
Middle Aged
Proviruses/genetics
Reverse Transcriptase Inhibitors/*therapeutic use
Tonsil/pathology/virology
*Viral Load
Virus Replication
Zidovudine/*therapeutic use
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/01/2008 16:13
Dernière modification de la notice
14/02/2022 8:54