Virus burden in lymph nodes and blood of subjects with primary human immunodeficiency virus type 1 infection on bitherapy

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Ressource 1Download: serval:BIB_24FEFC536E15.P001 (1586.88 [Ko])
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Serval ID
serval:BIB_24FEFC536E15
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Virus burden in lymph nodes and blood of subjects with primary human immunodeficiency virus type 1 infection on bitherapy
Journal
Journal of Infectious Diseases
Author(s)
Perrin  L., Yerly  S., Marchal  F., Schockmel  G. A., Hirschel  B., Fox  C. H., Pantaleo  G.
ISSN
0022-1899 (Print)
Publication state
Published
Issued date
06/1998
Volume
177
Number
6
Pages
1497-501
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jun
Abstract
At present, it is not known whether undetectable plasma viremia corresponds to an absence of human immunodeficiency virus type 1 (HIV-1) replication in lymphoid tissues. This issue has been explored in 11 subjects with primary HIV-1 infection treated with zidovudine plus didanosine by evaluating virologic markers in blood and lymphoid tissues 9-18 months after initiation of treatment. These markers include plasma viremia, measured with a sensitive assay with a detection limit of 20 HIV-1 RNA copies/mL, infectious virus titers and proviral DNA in lymph node mononuclear cells, and HIV-1 RNA in lymphoid tissue. Five subjects had plasma viremia <20 copies/mL and showed no evidence of viral replication in lymphoid tissue. Six subjects had both detectable plasma viremia and evidence of HIV-1 RNA in lymphoid tissue. The results indicate that absence of detectable HIV RNA in lymphoid tissue is associated with viremia levels of HIV-1 RNA <20 copies/mL.
Keywords
Adenoids/pathology/virology Adult Anti-HIV Agents/*therapeutic use CD4-CD8 Ratio DNA, Viral/analysis Dendritic Cells/virology Didanosine/*therapeutic use Drug Therapy, Combination Female HIV Infections/*drug therapy/pathology/*virology HIV-1/genetics/*physiology Humans Lymph Nodes/pathology/*virology Male Middle Aged Proviruses/genetics Reverse Transcriptase Inhibitors/*therapeutic use Tonsil/pathology/virology *Viral Load Virus Replication Zidovudine/*therapeutic use
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 15:13
Last modification date
25/09/2019 6:08
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