Developmental and pathological lymphangiogenesis: from models to human disease.

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Etat: Public
Version: Final published version
Licence: Non spécifiée
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ID Serval
serval:BIB_24ACB8BC5973
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Developmental and pathological lymphangiogenesis: from models to human disease.
Périodique
Histochemistry and Cell Biology
Auteur⸱e⸱s
Maby-El Hajjami H., Petrova T.V.
ISSN
0948-6143
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
130
Numéro
6
Pages
1063-1078
Langue
anglais
Résumé
The lymphatic vascular system, the body's second vascular system present in vertebrates, has emerged in recent years as a crucial player in normal and pathological processes. It participates in the maintenance of normal tissue fluid balance, the immune functions of cellular and antigen trafficking and absorption of fatty acids and lipid-soluble vitamins in the gut. Recent scientific discoveries have highlighted the role of lymphatic system in a number of pathologic conditions, including lymphedema, inflammatory diseases, and tumor metastasis. Development of genetically modified animal models, identification of lymphatic endothelial specific markers and regulators coupled with technological advances such as high-resolution imaging and genome-wide approaches have been instrumental in understanding the major steps controlling growth and remodeling of lymphatic vessels. This review highlights the recent insights and developments in the field of lymphatic vascular biology.
Mots-clé
Animals, Cell Differentiation, Cell Proliferation, Disease Models, Animal, Endothelium, Lymphatic, Humans, Inflammation, Lymphangiogenesis, Lymphatic Vessels, Lymphedema, Neoplasm Metastasis, Neoplasms, Signal Transduction
Pubmed
Web of science
Open Access
Oui
Création de la notice
01/04/2009 14:50
Dernière modification de la notice
14/02/2022 7:54
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