Developmental and pathological lymphangiogenesis: from models to human disease.

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Serval ID
serval:BIB_24ACB8BC5973
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Developmental and pathological lymphangiogenesis: from models to human disease.
Journal
Histochemistry and Cell Biology
Author(s)
Maby-El Hajjami H., Petrova T.V.
ISSN
0948-6143
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
130
Number
6
Pages
1063-1078
Language
english
Abstract
The lymphatic vascular system, the body's second vascular system present in vertebrates, has emerged in recent years as a crucial player in normal and pathological processes. It participates in the maintenance of normal tissue fluid balance, the immune functions of cellular and antigen trafficking and absorption of fatty acids and lipid-soluble vitamins in the gut. Recent scientific discoveries have highlighted the role of lymphatic system in a number of pathologic conditions, including lymphedema, inflammatory diseases, and tumor metastasis. Development of genetically modified animal models, identification of lymphatic endothelial specific markers and regulators coupled with technological advances such as high-resolution imaging and genome-wide approaches have been instrumental in understanding the major steps controlling growth and remodeling of lymphatic vessels. This review highlights the recent insights and developments in the field of lymphatic vascular biology.
Keywords
Animals, Cell Differentiation, Cell Proliferation, Disease Models, Animal, Endothelium, Lymphatic, Humans, Inflammation, Lymphangiogenesis, Lymphatic Vessels, Lymphedema, Neoplasm Metastasis, Neoplasms, Signal Transduction
Pubmed
Web of science
Open Access
Yes
Create date
01/04/2009 14:50
Last modification date
25/09/2019 6:08
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