The transcription factor Prox1 is essential for satellite cell differentiation and muscle fibre-type regulation.

Détails

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Etat: Public
Version: Final published version
ID Serval
serval:BIB_216872926482
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
The transcription factor Prox1 is essential for satellite cell differentiation and muscle fibre-type regulation.
Périodique
Nature Communications
Auteur(s)
Kivelä R., Salmela I., Nguyen Y.H., Petrova T.V., Koistinen H.A., Wiener Z., Alitalo K.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
7
Pages
13124
Langue
anglais
Résumé
The remarkable adaptive and regenerative capacity of skeletal muscle is regulated by several transcription factors and pathways. Here we show that the transcription factor Prox1 is an important regulator of myoblast differentiation and of slow muscle fibre type. In both rodent and human skeletal muscles Prox1 is specifically expressed in slow muscle fibres and in muscle stem cells called satellite cells. Prox1 activates the NFAT signalling pathway and is necessary and sufficient for the maintenance of the gene program of slow muscle fibre type. Using lineage-tracing we show that Prox1-positive satellite cells differentiate into muscle fibres. Furthermore, we provide evidence that Prox1 is a critical transcription factor for the differentiation of myoblasts via bi-directional crosstalk with Notch1. These results identify Prox1 as an essential transcription factor that regulates skeletal muscle phenotype and myoblast differentiation by interacting with the NFAT and Notch pathways.
Pubmed
Open Access
Oui
Création de la notice
19/10/2016 11:27
Dernière modification de la notice
20/08/2019 12:58
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