The transcription factor Prox1 is essential for satellite cell differentiation and muscle fibre-type regulation.

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Version: Final published version
Serval ID
serval:BIB_216872926482
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The transcription factor Prox1 is essential for satellite cell differentiation and muscle fibre-type regulation.
Journal
Nature Communications
Author(s)
Kivelä R., Salmela I., Nguyen Y.H., Petrova T.V., Koistinen H.A., Wiener Z., Alitalo K.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Publication state
Published
Issued date
2016
Peer-reviewed
Oui
Volume
7
Pages
13124
Language
english
Abstract
The remarkable adaptive and regenerative capacity of skeletal muscle is regulated by several transcription factors and pathways. Here we show that the transcription factor Prox1 is an important regulator of myoblast differentiation and of slow muscle fibre type. In both rodent and human skeletal muscles Prox1 is specifically expressed in slow muscle fibres and in muscle stem cells called satellite cells. Prox1 activates the NFAT signalling pathway and is necessary and sufficient for the maintenance of the gene program of slow muscle fibre type. Using lineage-tracing we show that Prox1-positive satellite cells differentiate into muscle fibres. Furthermore, we provide evidence that Prox1 is a critical transcription factor for the differentiation of myoblasts via bi-directional crosstalk with Notch1. These results identify Prox1 as an essential transcription factor that regulates skeletal muscle phenotype and myoblast differentiation by interacting with the NFAT and Notch pathways.
Pubmed
Open Access
Yes
Create date
19/10/2016 11:27
Last modification date
20/08/2019 12:58
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