Pharmacokinetic interaction between methotrexate and chloral hydrate.

Détails

Ressource 1Demande d'une copie Sous embargo indéterminé.
Accès restreint UNIL
Etat: Public
Version: Final published version
Licence: Tous droits réservés
ID Serval
serval:BIB_2011B1C22106
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
Pharmacokinetic interaction between methotrexate and chloral hydrate.
Périodique
Pediatric Blood and Cancer
Auteur⸱e⸱s
Dao K., Ivanyuk A., Buclin T., Beck-Popovic M., Diezi M.
ISSN
1545-5017 (Electronic)
ISSN-L
1545-5009
Statut éditorial
Publié
Date de publication
2013
Volume
60
Numéro
3
Pages
518-520
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish PDF type: Case report
Résumé
We report the case of a drug interaction between methotrexate (MTX) and chloral hydrate (CH) observed in a child treated for acute leukemia. Significantly slower MTX clearance and increased MTX exposure occurred on the first three courses of a high-dose chemotherapy when co-administered with CH despite normal renal function, adequate hydration, and alkalinization. Mean MTX area under the curve associated with CH administration was 1,134 µmol hours/L, compared to 608 µmol hours/L after discontinuation of CH. This interaction possibly resulted from a competition between anionic CH metabolites and MTX for renal tubular excretion.
Pubmed
Web of science
Création de la notice
01/03/2013 17:46
Dernière modification de la notice
27/04/2021 8:44
Données d'usage