Pharmacokinetic interaction between methotrexate and chloral hydrate.

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State: Public
Version: Final published version
License: All rights reserved
Serval ID
serval:BIB_2011B1C22106
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Pharmacokinetic interaction between methotrexate and chloral hydrate.
Journal
Pediatric Blood and Cancer
Author(s)
Dao K., Ivanyuk A., Buclin T., Beck-Popovic M., Diezi M.
ISSN
1545-5017 (Electronic)
ISSN-L
1545-5009
Publication state
Published
Issued date
2013
Volume
60
Number
3
Pages
518-520
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish PDF type: Case report
Abstract
We report the case of a drug interaction between methotrexate (MTX) and chloral hydrate (CH) observed in a child treated for acute leukemia. Significantly slower MTX clearance and increased MTX exposure occurred on the first three courses of a high-dose chemotherapy when co-administered with CH despite normal renal function, adequate hydration, and alkalinization. Mean MTX area under the curve associated with CH administration was 1,134 µmol hours/L, compared to 608 µmol hours/L after discontinuation of CH. This interaction possibly resulted from a competition between anionic CH metabolites and MTX for renal tubular excretion.
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Web of science
Create date
01/03/2013 18:46
Last modification date
20/08/2019 13:55
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