Dietary fish oil is antihypertrophic but does not enhance postischemic myocardial function in female mice.

Détails

ID Serval
serval:BIB_1E5E0BD1BCDE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Dietary fish oil is antihypertrophic but does not enhance postischemic myocardial function in female mice.
Périodique
American journal of physiology. Heart and circulatory physiology
Auteur(s)
Huggins C.E., Curl C.L., Patel R., McLennan P.L., Theiss M.L., Pedrazzini T., Pepe S., Delbridge L.M.
ISSN
0363-6135
Statut éditorial
Publié
Date de publication
2009
Volume
296
Numéro
4
Pages
H957-H966
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
Clinically and experimentally, a case for omega-3 polyunsaturated fatty acid (PUFA) cardioprotection in females has not been clearly established. The goal of this study was to investigate whether dietary omega-3 PUFA supplementation could provide ischemic protection in female mice with an underlying genetic predisposition to cardiac hypertrophy. Mature female transgenic mice (TG) with cardiac-specific overexpression of angiotensinogen that develop normotensive cardiac hypertrophy and littermate wild-type (WT) mice were fed a fish oil-derived diet (FO) or PUFA-matched control diet (CTR) for 4 wk. Myocardial membrane lipids, ex vivo cardiac performance (intraventricular balloon) after global no-flow ischemia and reperfusion (15/30 min), and reperfusion arrhythmia incidence were assessed. FO diet suppressed cardiac growth by 5% and 10% in WT and TG, respectively (P < 0.001). The extent of mechanical recovery [rate-pressure product (RPP) = beats/min x mmHg] of FO-fed WT and TG hearts was similar (50 +/- 7% vs. 45 +/- 12%, 30 min reperfusion), and this was not significantly different from CTR-fed WT or TG. To evaluate whether systemic estrogen was masking a protective effect of the FO diet, the responses of ovariectomized (OVX) WT and TG mice to FO dietary intervention were assessed. The extent of mechanical recovery of FO-fed OVX WT and TG (RPP, 50 +/- 4% vs. 64 +/- 8%) was not enhanced compared with CTR-fed mice (RPP, 60 +/- 11% vs. 80 +/- 8%, P = 0.335). Dietary FO did not suppress the incidence of reperfusion arrhythmias in WT or TG hearts (ovary-intact mice or OVX). Our findings indicate a lack of cardioprotective effect of dietary FO in females, determined by assessment of mechanical and arrhythmic activity postischemia in a murine ex vivo heart model.
Mots-clé
Angiotensin II/genetics, Angiotensin II/metabolism, Angiotensinogen/genetics, Angiotensinogen/metabolism, Animals, Arrhythmias, Cardiac/etiology, Dietary Fats, Unsaturated/pharmacology, Disease Models, Animal, Estrogens/metabolism, Female, Fish Oils/pharmacology, Genetic Predisposition to Disease/genetics, Hypertrophy/genetics, Hypertrophy/prevention & control, Mice, Mice, Transgenic, Myocardial Ischemia/complications, Myocardial Ischemia/physiopathology, Myocardium/metabolism, Myocardium/pathology, Ovariectomy, Reperfusion Injury/complications, Reperfusion Injury/physiopathology
Pubmed
Web of science
Création de la notice
03/02/2010 18:19
Dernière modification de la notice
20/08/2019 13:54
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