Placebo effect characteristics observed in a single, international, longitudinal study in Huntington's disease.
Détails
ID Serval
serval:BIB_1E5328A53063
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Placebo effect characteristics observed in a single, international, longitudinal study in Huntington's disease.
Périodique
Movement Disorders
Collaborateur⸱rice⸱s
European Huntington's Disease Initiative Study Group
Contributeur⸱rice⸱s
Zangerl A., Seppi K., Wenning G., Poewe W., Foeldy D., Auff E., Schober T., Wenzel K., Ott E., Walli J., Leblhuber F., Dürr A., Bloch F., Messouak O., Tallaksen C., Dubois B., Guillamo JS., Bachoud-Lévi AC., Engles A., Krystkowiak P., Destée A., Memin A., Thibaut-Tanchou S., Pasquier F., Azulay JP., Demonet JF., Galitzky M., Rascol O., Mollion H., Broussolle E., Madigand M., Lallement F., Goizet C., Tison F., Arguillère S., Viallet F., Bakchine S., Khoris J., Pages M., Camu W., Resch F., Hannequin D., Durif F., Saudeau D., Autret A., Andrich J., Saft C., Kraus PH., Przuntek H., Ecker D., Kramer B., Landwehrmeyer GB., Ludolph AC., Priller J., Meierkord H., Kuznik D., Dose M., Squitieri F., Albanese A., Abbruzzese G., Filla A., van de Warrenburg B., de Jong D., Kremer H., van Vugt J., Grimbergen Y., Roos R., Gawel M., Janik P., Kowalczys H., Pilczuk B., Kwiecinski H., Świat M., Ochudło S., Modestowicz R., Niezgoda A., łukasik M., Lukasik M., de Yébenes JG. , García-Ruiz P., Descals£££A Martínez£££ AM. , Rojo A., Fontán A., Hernández J., Cantarero S., Fanjul S., Alegre J., Roldán SG., Mateo D., Burguera JA., Solis P., Calopa M., Jaumà S., Bas J., Tolosa E., Muñoz JE., Gámez J., Cervera C., Zarranz JJ., Lezcano E., Gómez JC., Chacón J., Dinca L., Gamero MA., Redondo L., Castro A., Sesar A., López del Val J., López E., Ríos C., Castillio V., Burgunder JM., Nirkko A., Kälin A., Vingerhoets F., Wider C.
ISSN
1531-8257 (Electronic)
ISSN-L
0885-3185
Statut éditorial
Publié
Date de publication
2012
Volume
27
Numéro
3
Pages
439-442
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
BACKGROUND: Classically, clinical trials are based on the placebo-control design. Our aim was to analyze the placebo effect in Huntington's disease.
METHODS: Placebo data were obtained from an international, longitudinal, placebo-controlled trial for Huntington's disease (European Huntington's Disease Initiative Study Group). One-hundred and eighty patients were evaluated using the Unified Huntington Disease Rating Scale over 36 months. A placebo effect was defined as an improvement of at least 50% over baseline scores in the Unified Huntington Disease Rating Scale, and clinically relevant when at least 10% of the population met it.
RESULTS: Only behavior showed a significant placebo effect, and the proportion of the patients with placebo effect ranged from 16% (first visit) to 41% (last visit). Nondepressed patients with better functional status were most likely to be placebo-responders over time.
CONCLUSIONS: In Huntington's disease, behavior seems to be more vulnerable to placebo than overall motor function, cognition, and function
METHODS: Placebo data were obtained from an international, longitudinal, placebo-controlled trial for Huntington's disease (European Huntington's Disease Initiative Study Group). One-hundred and eighty patients were evaluated using the Unified Huntington Disease Rating Scale over 36 months. A placebo effect was defined as an improvement of at least 50% over baseline scores in the Unified Huntington Disease Rating Scale, and clinically relevant when at least 10% of the population met it.
RESULTS: Only behavior showed a significant placebo effect, and the proportion of the patients with placebo effect ranged from 16% (first visit) to 41% (last visit). Nondepressed patients with better functional status were most likely to be placebo-responders over time.
CONCLUSIONS: In Huntington's disease, behavior seems to be more vulnerable to placebo than overall motor function, cognition, and function
Mots-clé
Adult, Aged, Clinical Trials as Topic, Databases, Bibliographic/statistics & numerical data, Disability Evaluation, Female, Humans, Huntington Disease/therapy, Internationality, Longitudinal Studies, Male, Middle Aged, Placebo Effect, Placebos/therapeutic use, Retrospective Studies, Severity of Illness Index, Treatment Outcome
Pubmed
Web of science
Création de la notice
12/02/2013 16:07
Dernière modification de la notice
20/08/2019 12:54
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