Placebo effect characteristics observed in a single, international, longitudinal study in Huntington's disease.
Details
Serval ID
serval:BIB_1E5328A53063
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Placebo effect characteristics observed in a single, international, longitudinal study in Huntington's disease.
Journal
Movement Disorders
Working group(s)
European Huntington's Disease Initiative Study Group
Contributor(s)
Zangerl A., Seppi K., Wenning G., Poewe W., Foeldy D., Auff E., Schober T., Wenzel K., Ott E., Walli J., Leblhuber F., Dürr A., Bloch F., Messouak O., Tallaksen C., Dubois B., Guillamo JS., Bachoud-Lévi AC., Engles A., Krystkowiak P., Destée A., Memin A., Thibaut-Tanchou S., Pasquier F., Azulay JP., Demonet JF., Galitzky M., Rascol O., Mollion H., Broussolle E., Madigand M., Lallement F., Goizet C., Tison F., Arguillère S., Viallet F., Bakchine S., Khoris J., Pages M., Camu W., Resch F., Hannequin D., Durif F., Saudeau D., Autret A., Andrich J., Saft C., Kraus PH., Przuntek H., Ecker D., Kramer B., Landwehrmeyer GB., Ludolph AC., Priller J., Meierkord H., Kuznik D., Dose M., Squitieri F., Albanese A., Abbruzzese G., Filla A., van de Warrenburg B., de Jong D., Kremer H., van Vugt J., Grimbergen Y., Roos R., Gawel M., Janik P., Kowalczys H., Pilczuk B., Kwiecinski H., Świat M., Ochudło S., Modestowicz R., Niezgoda A., łukasik M., Lukasik M., de Yébenes JG. , García-Ruiz P., Descals£££A Martínez£££ AM. , Rojo A., Fontán A., Hernández J., Cantarero S., Fanjul S., Alegre J., Roldán SG., Mateo D., Burguera JA., Solis P., Calopa M., Jaumà S., Bas J., Tolosa E., Muñoz JE., Gámez J., Cervera C., Zarranz JJ., Lezcano E., Gómez JC., Chacón J., Dinca L., Gamero MA., Redondo L., Castro A., Sesar A., López del Val J., López E., Ríos C., Castillio V., Burgunder JM., Nirkko A., Kälin A., Vingerhoets F., Wider C.
ISSN
1531-8257 (Electronic)
ISSN-L
0885-3185
Publication state
Published
Issued date
2012
Volume
27
Number
3
Pages
439-442
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
BACKGROUND: Classically, clinical trials are based on the placebo-control design. Our aim was to analyze the placebo effect in Huntington's disease.
METHODS: Placebo data were obtained from an international, longitudinal, placebo-controlled trial for Huntington's disease (European Huntington's Disease Initiative Study Group). One-hundred and eighty patients were evaluated using the Unified Huntington Disease Rating Scale over 36 months. A placebo effect was defined as an improvement of at least 50% over baseline scores in the Unified Huntington Disease Rating Scale, and clinically relevant when at least 10% of the population met it.
RESULTS: Only behavior showed a significant placebo effect, and the proportion of the patients with placebo effect ranged from 16% (first visit) to 41% (last visit). Nondepressed patients with better functional status were most likely to be placebo-responders over time.
CONCLUSIONS: In Huntington's disease, behavior seems to be more vulnerable to placebo than overall motor function, cognition, and function
METHODS: Placebo data were obtained from an international, longitudinal, placebo-controlled trial for Huntington's disease (European Huntington's Disease Initiative Study Group). One-hundred and eighty patients were evaluated using the Unified Huntington Disease Rating Scale over 36 months. A placebo effect was defined as an improvement of at least 50% over baseline scores in the Unified Huntington Disease Rating Scale, and clinically relevant when at least 10% of the population met it.
RESULTS: Only behavior showed a significant placebo effect, and the proportion of the patients with placebo effect ranged from 16% (first visit) to 41% (last visit). Nondepressed patients with better functional status were most likely to be placebo-responders over time.
CONCLUSIONS: In Huntington's disease, behavior seems to be more vulnerable to placebo than overall motor function, cognition, and function
Keywords
Adult, Aged, Clinical Trials as Topic, Databases, Bibliographic/statistics & numerical data, Disability Evaluation, Female, Humans, Huntington Disease/therapy, Internationality, Longitudinal Studies, Male, Middle Aged, Placebo Effect, Placebos/therapeutic use, Retrospective Studies, Severity of Illness Index, Treatment Outcome
Pubmed
Web of science
Create date
12/02/2013 16:07
Last modification date
20/08/2019 12:54
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