c-Jun N-terminal kinase pathway inhibition in intracerebral hemorrhage.

Détails

ID Serval
serval:BIB_1E2392ADCE6C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
c-Jun N-terminal kinase pathway inhibition in intracerebral hemorrhage.
Périodique
Cerebrovascular Diseases
Auteur(s)
Michel-Monigadon Delphine, Bonny Christophe, Hirt Lorenz
ISSN
1421-9786[electronic], 1015-9770[linking]
Statut éditorial
Publié
Date de publication
2010
Volume
29
Numéro
6
Pages
564-570
Langue
anglais
Résumé
Background: Inhibition of the c-Jun N-terminal kinase (JNK) pathway by the TAT-coupled peptide XG-102 (formerly D-JNKI1) induces strong neuroprotection in ischemic stroke in rodents. We investigated the effect of JNK inhibition in intracerebral hemorrhage (ICH).
Methods: Three hours after induction of ICH by intrastriatal collagenase injection in mice, the animals received an intravenous injection of 100 mu g/kg of XG-102. The neurological outcome was assessed daily and the mice were sacrificed at 6 h, 1, 2 or 5 days after ICH.
Results: XG-102 administration significantly improved the neurological outcome at 1 day (p < 0.01). The lesion volume was significantly decreased after 2 days (29 +/- 11 vs. 39 +/- 5 mm(3) in vehicle-treated animals, p < 0.05). There was also a decreased hemispheric swelling (14 +/- 13 vs. 26 +/- 9% in vehicle-treated animals, p < 0.05) correlating with increased aquaporin 4 expression.
Conclusions: XG-102 attenuates cerebral edema in ICH and functional impairment at early time points. The beneficial effects observed with XG-102 in ICH, as well as in ischemic stroke, open the possibility to rapidly treat stroke patients before imaging, thereby saving precious time.
Mots-clé
Stroke, Intracerebral Hemorrhage, JNK Pathway, XG-102, Aquaporin, Cerebral-Ischemia, Brain-Injury, Subarachnoid Hemorrhage, Aquaporin-4 Expression, Peptide Inhibitor, Thrombin, Protects, Edema, Iron, Activation
Pubmed
Web of science
Création de la notice
14/06/2010 12:10
Dernière modification de la notice
20/08/2019 12:54
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