c-Jun N-terminal kinase pathway inhibition in intracerebral hemorrhage.

Details

Serval ID
serval:BIB_1E2392ADCE6C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
c-Jun N-terminal kinase pathway inhibition in intracerebral hemorrhage.
Journal
Cerebrovascular Diseases
Author(s)
Michel-Monigadon Delphine, Bonny Christophe, Hirt Lorenz
ISSN
1421-9786[electronic], 1015-9770[linking]
Publication state
Published
Issued date
2010
Volume
29
Number
6
Pages
564-570
Language
english
Abstract
Background: Inhibition of the c-Jun N-terminal kinase (JNK) pathway by the TAT-coupled peptide XG-102 (formerly D-JNKI1) induces strong neuroprotection in ischemic stroke in rodents. We investigated the effect of JNK inhibition in intracerebral hemorrhage (ICH).
Methods: Three hours after induction of ICH by intrastriatal collagenase injection in mice, the animals received an intravenous injection of 100 mu g/kg of XG-102. The neurological outcome was assessed daily and the mice were sacrificed at 6 h, 1, 2 or 5 days after ICH.
Results: XG-102 administration significantly improved the neurological outcome at 1 day (p < 0.01). The lesion volume was significantly decreased after 2 days (29 +/- 11 vs. 39 +/- 5 mm(3) in vehicle-treated animals, p < 0.05). There was also a decreased hemispheric swelling (14 +/- 13 vs. 26 +/- 9% in vehicle-treated animals, p < 0.05) correlating with increased aquaporin 4 expression.
Conclusions: XG-102 attenuates cerebral edema in ICH and functional impairment at early time points. The beneficial effects observed with XG-102 in ICH, as well as in ischemic stroke, open the possibility to rapidly treat stroke patients before imaging, thereby saving precious time.
Keywords
Stroke, Intracerebral Hemorrhage, JNK Pathway, XG-102, Aquaporin, Cerebral-Ischemia, Brain-Injury, Subarachnoid Hemorrhage, Aquaporin-4 Expression, Peptide Inhibitor, Thrombin, Protects, Edema, Iron, Activation
Pubmed
Web of science
Create date
14/06/2010 12:10
Last modification date
20/08/2019 12:54
Usage data