Polyfunctional HCV-specific T-cell responses are associated with effective control of HCV replication.
Détails
ID Serval
serval:BIB_1D7CF05887AD
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Polyfunctional HCV-specific T-cell responses are associated with effective control of HCV replication.
Périodique
European Journal of Immunology
ISSN
0014-2980[print], 0014-2980[linking]
Statut éditorial
Publié
Date de publication
2008
Volume
38
Numéro
10
Pages
2665-2677
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
HCV infection has a severe course of disease in HIV/HCV co-infection and in liver transplant recipients. However, the mechanisms involved remain unclear. Here, we evaluated functional profiles of HCV-specific T-cell responses in 86 HCV mono-infected patients, 48 HIV/HCV co-infected patients and 42 liver transplant recipients. IFN-gamma and IL-2 production and ability of CD4 and CD8 T cells to proliferate were assessed after stimulation with HCV-derived peptides. We observed that HCV-specific T-cell responses were polyfunctional in HCV mono-infected patients, with presence of proliferating single IL-2-, dual IL-2/IFN-gamma and single IFN-gamma-producing CD4+ and dual IL-2/IFN-gamma and single IFN-gamma-producing CD8+ cells. In contrast, HCV-specific T-cell responses had an effector profile in HIV/HCV co-infected individuals and liver transplant recipients with absence of single IL-2-producing HCV-specific CD4+ and dual IL-2/IFN-gamma-producing CD8+ T cells. In addition, HCV-specific proliferation of CD4+ and CD8+ T cells was severely impaired in HIV/HCV co-infected patients and liver transplant recipients. Importantly, "only effector" T-cell responses were associated with significantly higher HCV viral load and more severe liver fibrosis scores. Therefore, the present results suggest that immune-based mechanisms may contribute to explain the accelerated course of HCV infection in conditions of HIV-1 co-infection and liver transplantation.
Mots-clé
CD4-Positive T-Lymphocytes/immunology, CD8-Positive T-Lymphocytes/immunology, HIV/immunology, HIV Infections/complications, HIV Infections/immunology, Hepacivirus/immunology, Hepacivirus/physiology, Hepatitis C, Chronic/complications, Hepatitis C, Chronic/immunology, Humans, Interferon-gamma/immunology, Interferon-gamma/metabolism, Interleukin-2/immunology, Interleukin-2/metabolism, Liver Transplantation/immunology, Viral Load, Virus Replication
Pubmed
Web of science
Open Access
Oui
Création de la notice
22/01/2009 12:04
Dernière modification de la notice
20/08/2019 13:53