Polyfunctional HCV-specific T-cell responses are associated with effective control of HCV replication.

Détails

ID Serval
serval:BIB_1D7CF05887AD
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Polyfunctional HCV-specific T-cell responses are associated with effective control of HCV replication.
Périodique
European Journal of Immunology
Auteur(s)
Ciuffreda D., Comte D., Cavassini M., Giostra E., Bühler L., Perruchoud M., Heim M.H., Battegay M., Genné D., Mulhaupt B., Malinverni R., Oneta C., Bernasconi E., Monnat M., Cerny A., Chuard C., Borovicka J., Mentha G., Pascual M., Gonvers J.J., Pantaleo G., Dutoit V.
ISSN
0014-2980[print], 0014-2980[linking]
Statut éditorial
Publié
Date de publication
2008
Volume
38
Numéro
10
Pages
2665-2677
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
HCV infection has a severe course of disease in HIV/HCV co-infection and in liver transplant recipients. However, the mechanisms involved remain unclear. Here, we evaluated functional profiles of HCV-specific T-cell responses in 86 HCV mono-infected patients, 48 HIV/HCV co-infected patients and 42 liver transplant recipients. IFN-gamma and IL-2 production and ability of CD4 and CD8 T cells to proliferate were assessed after stimulation with HCV-derived peptides. We observed that HCV-specific T-cell responses were polyfunctional in HCV mono-infected patients, with presence of proliferating single IL-2-, dual IL-2/IFN-gamma and single IFN-gamma-producing CD4+ and dual IL-2/IFN-gamma and single IFN-gamma-producing CD8+ cells. In contrast, HCV-specific T-cell responses had an effector profile in HIV/HCV co-infected individuals and liver transplant recipients with absence of single IL-2-producing HCV-specific CD4+ and dual IL-2/IFN-gamma-producing CD8+ T cells. In addition, HCV-specific proliferation of CD4+ and CD8+ T cells was severely impaired in HIV/HCV co-infected patients and liver transplant recipients. Importantly, "only effector" T-cell responses were associated with significantly higher HCV viral load and more severe liver fibrosis scores. Therefore, the present results suggest that immune-based mechanisms may contribute to explain the accelerated course of HCV infection in conditions of HIV-1 co-infection and liver transplantation.
Mots-clé
CD4-Positive T-Lymphocytes/immunology, CD8-Positive T-Lymphocytes/immunology, HIV/immunology, HIV Infections/complications, HIV Infections/immunology, Hepacivirus/immunology, Hepacivirus/physiology, Hepatitis C, Chronic/complications, Hepatitis C, Chronic/immunology, Humans, Interferon-gamma/immunology, Interferon-gamma/metabolism, Interleukin-2/immunology, Interleukin-2/metabolism, Liver Transplantation/immunology, Viral Load, Virus Replication
Pubmed
Web of science
Open Access
Oui
Création de la notice
22/01/2009 11:04
Dernière modification de la notice
20/08/2019 12:53
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