Treatment of primary pulmonary hypertension with nifedipine. A hemodynamic and scintigraphic evaluation

Détails

ID Serval
serval:BIB_1D7A813C6108
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Treatment of primary pulmonary hypertension with nifedipine. A hemodynamic and scintigraphic evaluation
Périodique
Annals of Internal Medicine
Auteur(s)
Rubin  L. J., Nicod  P., Hillis  L. D., Firth  B. G.
ISSN
0003-4819 (Print)
Statut éditorial
Publié
Date de publication
10/1983
Volume
99
Numéro
4
Pages
433-8
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Oct
Résumé
To evaluate the potential value of nifedipine treatment for primary pulmonary hypertension, hemodynamic and scintigraphic measurements were made before and 15 to 30 minutes after nifedipine, 10 to 20 mg, was given sublingually to nine patients. Nifedipine treatment increased cardiac output (mean +/- SD, 3.6 +/- 1.7 to 5.3 +/- 2.8 L/min, p less than 0.001) and decreased mean aortic pressure (99 +/- 19 to 85 +/- 12 mm Hg, p less than 0.001) and total pulmonary and total systemic resistances (1605 +/- 787 to 1025 +/- 540 dyn X s X cm-5 and 2761 +/- 1557 to 1591 +/- 823 dyn X s X cm-5, respectively; p less than 0.005). Heart rate and mean pulmonary arterial pressure did not change significantly. Right ventricular end-diastolic volume decreased 10% (p = 0.01), end-systolic volume decreased 15% (p less than 0.01), and right ventricular ejection fraction increased 18% (p less than 0.05) in eight patients. After 4 to 14 months (mean, 7.3 +/- 3.8) of treatment with nifedipine, 40 to 120 mg/d, in six patients, cardiac output increased (3.6 +/- 2.0 to 5.0 +/- 1.8 L/min, p less than 0.01) and total pulmonary resistance decreased (1572 +/- 730 to 987 +/- 586 dyn X s X cm-5, p = 0.025), whereas pulmonary arterial pressure remained unchanged (59 +/- 23.2 to 55 +/- 28.6 mm Hg, p greater than 0.05) compared with baseline values. We conclude that nifedipine therapy may be useful in the chronic management of patients with primary pulmonary hypertension.
Mots-clé
Adolescent Adult Aorta Blood Pressure/drug effects Cardiac Output/drug effects Female Heart Rate/drug effects Humans Hypertension, Pulmonary/*drug therapy/physiopathology/radionuclide imaging Male Middle Aged Nifedipine/*therapeutic use
Pubmed
Web of science
Création de la notice
25/01/2008 15:00
Dernière modification de la notice
20/08/2019 13:53
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