Treatment of primary pulmonary hypertension with nifedipine. A hemodynamic and scintigraphic evaluation
Details
Serval ID
serval:BIB_1D7A813C6108
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Treatment of primary pulmonary hypertension with nifedipine. A hemodynamic and scintigraphic evaluation
Journal
Annals of Internal Medicine
ISSN
0003-4819 (Print)
Publication state
Published
Issued date
10/1983
Volume
99
Number
4
Pages
433-8
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Oct
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Oct
Abstract
To evaluate the potential value of nifedipine treatment for primary pulmonary hypertension, hemodynamic and scintigraphic measurements were made before and 15 to 30 minutes after nifedipine, 10 to 20 mg, was given sublingually to nine patients. Nifedipine treatment increased cardiac output (mean +/- SD, 3.6 +/- 1.7 to 5.3 +/- 2.8 L/min, p less than 0.001) and decreased mean aortic pressure (99 +/- 19 to 85 +/- 12 mm Hg, p less than 0.001) and total pulmonary and total systemic resistances (1605 +/- 787 to 1025 +/- 540 dyn X s X cm-5 and 2761 +/- 1557 to 1591 +/- 823 dyn X s X cm-5, respectively; p less than 0.005). Heart rate and mean pulmonary arterial pressure did not change significantly. Right ventricular end-diastolic volume decreased 10% (p = 0.01), end-systolic volume decreased 15% (p less than 0.01), and right ventricular ejection fraction increased 18% (p less than 0.05) in eight patients. After 4 to 14 months (mean, 7.3 +/- 3.8) of treatment with nifedipine, 40 to 120 mg/d, in six patients, cardiac output increased (3.6 +/- 2.0 to 5.0 +/- 1.8 L/min, p less than 0.01) and total pulmonary resistance decreased (1572 +/- 730 to 987 +/- 586 dyn X s X cm-5, p = 0.025), whereas pulmonary arterial pressure remained unchanged (59 +/- 23.2 to 55 +/- 28.6 mm Hg, p greater than 0.05) compared with baseline values. We conclude that nifedipine therapy may be useful in the chronic management of patients with primary pulmonary hypertension.
Keywords
Adolescent
Adult
Aorta
Blood Pressure/drug effects
Cardiac Output/drug effects
Female
Heart Rate/drug effects
Humans
Hypertension, Pulmonary/*drug therapy/physiopathology/radionuclide imaging
Male
Middle Aged
Nifedipine/*therapeutic use
Pubmed
Web of science
Create date
25/01/2008 14:00
Last modification date
20/08/2019 12:53