HIV type 1 drug resistance among naive patients from Venezuela.
Détails
ID Serval
serval:BIB_1CC95C68F3C6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
HIV type 1 drug resistance among naive patients from Venezuela.
Périodique
AIDS Research and Human Retroviruses
ISSN
0889-2229
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
23
Numéro
3
Pages
482-485
Langue
anglais
Résumé
In this study, we characterize proviral DNA of 20 HIV-1 asymptomatic antiretroviral-naive patients from Venezuela in env, gag, and pol genes regions. Results from both env/gag HMA subtyping and phylogenetic analysis of pol partial sequences led to the description of clade B in all cases. Nevertheless, the high prevalence of polymorphisms was particularly evident among the protease sequences. A 10% prevalence of major resistance mutations to RTIs was found. Our data also suggested that the protease polymorphisms I62T and V77T could be considered as molecular markers of the subtype B local epidemic. In addition, we show how proviral DNA can be used as a reliable tool to follow trends of resistance mutation transmission.
Mots-clé
DNA Mutational Analysis, Drug Resistance, Multiple, Viral, Female, HIV Infections, HIV Protease, HIV Reverse Transcriptase, HIV-1, Humans, Male, Molecular Sequence Data, Phylogeny, Venezuela
Pubmed
Web of science
Création de la notice
31/03/2009 11:37
Dernière modification de la notice
20/08/2019 13:53