Article: article from journal or magazin.
HIV type 1 drug resistance among naive patients from Venezuela.
AIDS Research and Human Retroviruses
In this study, we characterize proviral DNA of 20 HIV-1 asymptomatic antiretroviral-naive patients from Venezuela in env, gag, and pol genes regions. Results from both env/gag HMA subtyping and phylogenetic analysis of pol partial sequences led to the description of clade B in all cases. Nevertheless, the high prevalence of polymorphisms was particularly evident among the protease sequences. A 10% prevalence of major resistance mutations to RTIs was found. Our data also suggested that the protease polymorphisms I62T and V77T could be considered as molecular markers of the subtype B local epidemic. In addition, we show how proviral DNA can be used as a reliable tool to follow trends of resistance mutation transmission.
DNA Mutational Analysis, Drug Resistance, Multiple, Viral, Female, HIV Infections, HIV Protease, HIV Reverse Transcriptase, HIV-1, Humans, Male, Molecular Sequence Data, Phylogeny, Venezuela
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