Brainstem Correlates of a Cold Pressor Test Measured by Ultra-High Field fMRI.

Détails

ID Serval
serval:BIB_1ADE37E4C3CF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Brainstem Correlates of a Cold Pressor Test Measured by Ultra-High Field fMRI.
Périodique
Frontiers in neuroscience
Auteur(s)
Hendriks-Balk M.C., Megdiche F., Pezzi L., Reynaud O., Da Costa S., Bueti D., Van De Ville D., Wuerzner G.
ISSN
1662-4548 (Print)
ISSN-L
1662-453X
Statut éditorial
Publié
Date de publication
2020
Peer-reviewed
Oui
Volume
14
Pages
39
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
Modern imaging techniques such as blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) allow the non-invasive and indirect measurement of brain activity. Whether changes in signal intensity can be detected in small brainstem regions during a cold pressor test (CPT) has not been explored thoroughly. The aim of this study was to measure whole brain and brainstem BOLD signal intensity changes in response to a modified CPT.
BOLD fMRI was measured in healthy normotensive participants during a randomized crossover study (modified CPT vs. control test) using ultra-high field 7 Tesla MRI scanner. Data were analyzed using Statistical Parametric Mapping (SPM) in a whole-brain approach, and with a brainstem-specific analysis using the spatially unbiased infra-tentorial template (SUIT) toolbox. Blood pressure (BP) and hormonal responses (norepinephrine and epinephrine levels) were also measured. Paired t-test statistics were used to compare conditions.
Eleven participants (six women, mean age 28 ± 8.9 years) were analyzed. Mean arterial BP increased from 83 ± 12 mm Hg to 87 ± 12 mm Hg (p = 0.0009) during the CPT. Whole-brain analysis revealed significant activations linked to the CPT in the right supplementary motor cortex, midcingulate (bilateral) and the right anterior insular cortex. The brainstem-specific analysis showed significant activations in the dorsal medulla.
Changes in BOLD fMRI signal intensity in brainstem regions during a CPT can be detected, and show an increased response during a cold stress in healthy volunteers. Consequently, BOLD fMRI at 7T is a promising tool to explore and acquire new insights in the comprehension of neurogenic hypertension.
Mots-clé
BOLD, blood pressure, brainstem, cold pressor test, fMRI, sympathetic nervous system
Pubmed
Open Access
Oui
Création de la notice
27/02/2020 15:48
Dernière modification de la notice
05/06/2020 5:26
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