Brainstem Correlates of a Cold Pressor Test Measured by Ultra-High Field fMRI.

Details

Serval ID
serval:BIB_1ADE37E4C3CF
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Brainstem Correlates of a Cold Pressor Test Measured by Ultra-High Field fMRI.
Journal
Frontiers in neuroscience
Author(s)
Hendriks-Balk M.C., Megdiche F., Pezzi L., Reynaud O., Da Costa S., Bueti D., Van De Ville D., Wuerzner G.
ISSN
1662-4548 (Print)
ISSN-L
1662-453X
Publication state
Published
Issued date
2020
Peer-reviewed
Oui
Volume
14
Pages
39
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Modern imaging techniques such as blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) allow the non-invasive and indirect measurement of brain activity. Whether changes in signal intensity can be detected in small brainstem regions during a cold pressor test (CPT) has not been explored thoroughly. The aim of this study was to measure whole brain and brainstem BOLD signal intensity changes in response to a modified CPT.
BOLD fMRI was measured in healthy normotensive participants during a randomized crossover study (modified CPT vs. control test) using ultra-high field 7 Tesla MRI scanner. Data were analyzed using Statistical Parametric Mapping (SPM) in a whole-brain approach, and with a brainstem-specific analysis using the spatially unbiased infra-tentorial template (SUIT) toolbox. Blood pressure (BP) and hormonal responses (norepinephrine and epinephrine levels) were also measured. Paired t-test statistics were used to compare conditions.
Eleven participants (six women, mean age 28 ± 8.9 years) were analyzed. Mean arterial BP increased from 83 ± 12 mm Hg to 87 ± 12 mm Hg (p = 0.0009) during the CPT. Whole-brain analysis revealed significant activations linked to the CPT in the right supplementary motor cortex, midcingulate (bilateral) and the right anterior insular cortex. The brainstem-specific analysis showed significant activations in the dorsal medulla.
Changes in BOLD fMRI signal intensity in brainstem regions during a CPT can be detected, and show an increased response during a cold stress in healthy volunteers. Consequently, BOLD fMRI at 7T is a promising tool to explore and acquire new insights in the comprehension of neurogenic hypertension.
Keywords
BOLD, blood pressure, brainstem, cold pressor test, fMRI, sympathetic nervous system
Pubmed
Open Access
Yes
Create date
27/02/2020 15:48
Last modification date
05/06/2020 5:26
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