SNAREing the basis of multicellularity: consequences of protein family expansion during evolution.

Détails

Ressource 1Télécharger: Kloepperetal_2008.pdf (3067.80 [Ko])
Etat: Public
Version: Author's accepted manuscript
ID Serval
serval:BIB_186B3DB1BD09
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
SNAREing the basis of multicellularity: consequences of protein family expansion during evolution.
Périodique
Molecular Biology and Evolution
Auteur(s)
Kloepper T.H., Kienle C.N., Fasshauer D.
ISSN
1537-1719 (Electronic)
ISSN-L
0737-4038
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
25
Numéro
9
Pages
2055-2068
Langue
anglais
Résumé
Vesicle trafficking between intracellular compartments of eukaryotic cells is mediated by conserved protein machineries. In each trafficking step, fusion of the vesicle with the acceptor membrane is driven by a set of distinctive soluble N-ethylmaleimide sensitive factor attachment protein receptor (SNARE) proteins that assemble into tight 4-helix bundle complexes between the fusing membranes. During evolution, about 20 primordial SNARE types were modified independently in different eukaryotic lineages by episodes of duplication and diversification. Here we show that 2 major changes in the SNARE repertoire occurred in the evolution of animals, each reflecting a main overhaul of the endomembrane system. In addition, we found several lineage-specific losses of distinct SNAREs, particularly in nematodes and platyhelminthes. The first major transformation took place during the transition to multicellularity. The primary event that occurred during this transformation was an increase in the numbers of endosomal SNAREs, but the SNARE-related factor lethal giant larvae also emerged. Apparently, enhanced endosomal sorting capabilities were an advantage for early multicellular animals. The second major transformation during the rise of vertebrates resulted in a robust expansion of the secretory set of SNAREs, which may have helped develop a more versatile secretory apparatus.
Mots-clé
Animals, Endosomes/metabolism, Eukaryotic Cells/physiology, Evolution, Molecular, Expressed Sequence Tags, Fishes/genetics, Gene Deletion, Gene Duplication, Genome, Humans, Invertebrates/genetics, Phylogeny, SNARE Proteins/classification, SNARE Proteins/genetics, Vertebrates/genetics
Pubmed
Web of science
Open Access
Oui
Création de la notice
15/09/2011 9:07
Dernière modification de la notice
20/08/2019 13:48
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