Pulse wave amplitude drops during sleep: clinical significance and characteristics in a general population sample.

Détails

Ressource 1Télécharger: 76. 2020 Hirotsu Sleep.pdf (1752.43 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY-NC-ND 4.0
ID Serval
serval:BIB_17B727F30EDF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Pulse wave amplitude drops during sleep: clinical significance and characteristics in a general population sample.
Périodique
Sleep
Auteur⸱e⸱s
Hirotsu C., Betta M., Bernardi G., Marques-Vidal P., Vollenweider P., Waeber G., Pichot V., Roche F., Siclari F., Haba-Rubio J., Heinzer R.
ISSN
1550-9109 (Electronic)
ISSN-L
0161-8105
Statut éditorial
Publié
Date de publication
13/07/2020
Peer-reviewed
Oui
Volume
43
Numéro
7
Pages
zsz322
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
To explore the clinical significance of pulse wave amplitude (PWA)-drops during sleep as a biomarker for cardiometabolic disorders and describe their main characteristics in a general population sample.
Cross-sectional study of HypnoLaus cohort, in which 2162 individuals underwent clinical assessment and in-home full polysomnography. PWA-drops were derived from photoplethysmography and processed using a validated automated algorithm. Associations between PWA-drop features (index, mean duration, and mean area under the curve [AUC]) with hypertension, diabetes, and previous cardiovascular (CV) event were analyzed using multivariable-adjusted logistic regression.
Two thousand one hundred forty-nine participants (59 ± 11 years, 51% women, 9.9% diabetes, 41.3% hypertension, 4.4% CV event) were included. Mean ± standard deviation (SD) of PWA-drop index, duration, and AUC during sleep were 51.0 ± 20.3 events/hour, 14.0 ± 2.7 seconds, and 527±115 %seconds, respectively. PWA-drop index was lower in women and decreased with age, while its mean duration and AUC increased in men and elderly. Overall, lower PWA-drop index, longer duration and greater AUC were associated with increased odds of hypertension, diabetes, or CV event after adjustment for confounders. Participants in the lowest quartile of mean duration-normalized PWA-drop index had a significantly higher odds ratio (OR) of hypertension (OR = 1.60 [1.19-2.16]), CV event (OR = 3.26 [1.33-8.03]), and diabetes (OR = 1.71 [1.06-2.76]) compared to those in the highest quartile. Similar results were observed for mean AUC-normalized PWA-drop index regarding hypertension (OR = 1.59 [1.19-2.13]), CV event (OR = 2.45 [1.14-5.26]) and diabetes (OR = 1.76 [1.10-2.83]).
PWA-drop features during sleep seem to be an interesting biomarker independently associated with cardiometabolic outcomes in the general population.
Mots-clé
autonomic nervous system, biomarkers, cardiovascular medicine, diabetes, epidemiology, hypertension
Pubmed
Web of science
Open Access
Oui
Création de la notice
29/01/2020 15:56
Dernière modification de la notice
11/02/2021 7:25
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