Pulse wave amplitude drops during sleep: clinical significance and characteristics in a general population sample.

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State: Public
Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_17B727F30EDF
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Pulse wave amplitude drops during sleep: clinical significance and characteristics in a general population sample.
Journal
Sleep
Author(s)
Hirotsu C., Betta M., Bernardi G., Marques-Vidal P., Vollenweider P., Waeber G., Pichot V., Roche F., Siclari F., Haba-Rubio J., Heinzer R.
ISSN
1550-9109 (Electronic)
ISSN-L
0161-8105
Publication state
Published
Issued date
13/07/2020
Peer-reviewed
Oui
Volume
43
Number
7
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
To explore the clinical significance of pulse wave amplitude (PWA)-drops during sleep as a biomarker for cardiometabolic disorders and describe their main characteristics in a general population sample.
Cross-sectional study of HypnoLaus cohort, in which 2162 individuals underwent clinical assessment and in-home full polysomnography. PWA-drops were derived from photoplethysmography and processed using a validated automated algorithm. Associations between PWA-drop features (index, mean duration, and mean area under the curve [AUC]) with hypertension, diabetes, and previous cardiovascular (CV) event were analyzed using multivariable-adjusted logistic regression.
Two thousand one hundred forty-nine participants (59 ± 11 years, 51% women, 9.9% diabetes, 41.3% hypertension, 4.4% CV event) were included. Mean ± standard deviation (SD) of PWA-drop index, duration, and AUC during sleep were 51.0 ± 20.3 events/hour, 14.0 ± 2.7 seconds, and 527±115 %seconds, respectively. PWA-drop index was lower in women and decreased with age, while its mean duration and AUC increased in men and elderly. Overall, lower PWA-drop index, longer duration and greater AUC were associated with increased odds of hypertension, diabetes, or CV event after adjustment for confounders. Participants in the lowest quartile of mean duration-normalized PWA-drop index had a significantly higher odds ratio (OR) of hypertension (OR = 1.60 [1.19-2.16]), CV event (OR = 3.26 [1.33-8.03]), and diabetes (OR = 1.71 [1.06-2.76]) compared to those in the highest quartile. Similar results were observed for mean AUC-normalized PWA-drop index regarding hypertension (OR = 1.59 [1.19-2.13]), CV event (OR = 2.45 [1.14-5.26]) and diabetes (OR = 1.76 [1.10-2.83]).
PWA-drop features during sleep seem to be an interesting biomarker independently associated with cardiometabolic outcomes in the general population.
Keywords
autonomic nervous system, biomarkers, cardiovascular medicine, diabetes, epidemiology, hypertension
Pubmed
Open Access
Yes
Create date
29/01/2020 14:56
Last modification date
08/08/2020 5:21
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