Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus

Détails

ID Serval
serval:BIB_1752B27B6637
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus
Périodique
Nature
Auteur(s)
Nierman  W. C., Pain  A., Anderson  M. J., Wortman  J. R., Kim  H. S., Arroyo  J., Berriman  M., Abe  K., Archer  D. B., Bermejo  C., Bennett  J., Bowyer  P., Chen  D., Collins  M., Coulsen  R., Davies  R., Dyer  P. S., Farman  M., Fedorova  N., Fedorova  N., Feldblyum  T. V., Fischer  R., Fosker  N., Fraser  A., Garcia  J. L., Garcia  M. J., Goble  A., Goldman  G. H., Gomi  K., Griffith-Jones  S., Gwilliam  R., Haas  B., Haas  H., Harris  D., Horiuchi  H., Huang  J., Humphray  S., Jimenez  J., Keller  N., Khouri  H., Kitamoto  K., Kobayashi  T., Konzack  S., Kulkarni  R., Kumagai  T., Lafon  A., Latge  J. P., Li  W., Lord  A., Lu  C., Majoros  W. H., May  G. S., Miller  B. L., Mohamoud  Y., Molina  M., Monod  M., Mouyna  I., Mulligan  S., Murphy  L., O'Neil  S., Paulsen  I., Penalva  M. A., Pertea  M., Price  C., Pritchard  B. L., Quail  M. A., Rabbinowitsch  E., Rawlins  N., Rajandream  M. A., Reichard  U., Renauld  H., Robson  G. D., Rodriguez de Cordoba  S., Rodriguez-Pena  J. M., Ronning  C. M., Rutter  S., Salzberg  S. L., Sanchez  M., Sanchez-Ferrero  J. C., Saunders  D., Seeger  K., Squares  R., Squares  S., Takeuchi  M., Tekaia  F., Turner  G., Vazquez de Aldana  C. R., Weidman  J., White  O., Woodward  J., Yu  J. H., Fraser  C., Galagan  J. E., Asai  K., Machida  M., Hall  N., Barrell  B., Denning  D. W.
ISSN
1476-4687 (Electronic)
Statut éditorial
Publié
Date de publication
12/2005
Volume
438
Numéro
7071
Pages
1151-6
Notes
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't --- Old month value: Dec 22
Résumé
Aspergillus fumigatus is exceptional among microorganisms in being both a primary and opportunistic pathogen as well as a major allergen. Its conidia production is prolific, and so human respiratory tract exposure is almost constant. A. fumigatus is isolated from human habitats and vegetable compost heaps. In immunocompromised individuals, the incidence of invasive infection can be as high as 50% and the mortality rate is often about 50% (ref. 2). The interaction of A. fumigatus and other airborne fungi with the immune system is increasingly linked to severe asthma and sinusitis. Although the burden of invasive disease caused by A. fumigatus is substantial, the basic biology of the organism is mostly obscure. Here we show the complete 29.4-megabase genome sequence of the clinical isolate Af293, which consists of eight chromosomes containing 9,926 predicted genes. Microarray analysis revealed temperature-dependent expression of distinct sets of genes, as well as 700 A. fumigatus genes not present or significantly diverged in the closely related sexual species Neosartorya fischeri, many of which may have roles in the pathogenicity phenotype. The Af293 genome sequence provides an unparalleled resource for the future understanding of this remarkable fungus.
Mots-clé
Allergens/*genetics Aspergillus fumigatus/*genetics/immunology/*pathogenicity Gene Expression Profiling Gene Expression Regulation, Fungal Genes, Fungal/genetics *Genome, Fungal *Genomics Hypersensitivity/*microbiology Molecular Sequence Data Oligonucleotide Array Sequence Analysis Sequence Analysis, DNA Temperature Virulence/genetics
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/01/2008 16:47
Dernière modification de la notice
20/08/2019 12:47
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