Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus


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Article: article from journal or magazin.
Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus
Nierman  W. C., Pain  A., Anderson  M. J., Wortman  J. R., Kim  H. S., Arroyo  J., Berriman  M., Abe  K., Archer  D. B., Bermejo  C., Bennett  J., Bowyer  P., Chen  D., Collins  M., Coulsen  R., Davies  R., Dyer  P. S., Farman  M., Fedorova  N., Fedorova  N., Feldblyum  T. V., Fischer  R., Fosker  N., Fraser  A., Garcia  J. L., Garcia  M. J., Goble  A., Goldman  G. H., Gomi  K., Griffith-Jones  S., Gwilliam  R., Haas  B., Haas  H., Harris  D., Horiuchi  H., Huang  J., Humphray  S., Jimenez  J., Keller  N., Khouri  H., Kitamoto  K., Kobayashi  T., Konzack  S., Kulkarni  R., Kumagai  T., Lafon  A., Latge  J. P., Li  W., Lord  A., Lu  C., Majoros  W. H., May  G. S., Miller  B. L., Mohamoud  Y., Molina  M., Monod  M., Mouyna  I., Mulligan  S., Murphy  L., O'Neil  S., Paulsen  I., Penalva  M. A., Pertea  M., Price  C., Pritchard  B. L., Quail  M. A., Rabbinowitsch  E., Rawlins  N., Rajandream  M. A., Reichard  U., Renauld  H., Robson  G. D., Rodriguez de Cordoba  S., Rodriguez-Pena  J. M., Ronning  C. M., Rutter  S., Salzberg  S. L., Sanchez  M., Sanchez-Ferrero  J. C., Saunders  D., Seeger  K., Squares  R., Squares  S., Takeuchi  M., Tekaia  F., Turner  G., Vazquez de Aldana  C. R., Weidman  J., White  O., Woodward  J., Yu  J. H., Fraser  C., Galagan  J. E., Asai  K., Machida  M., Hall  N., Barrell  B., Denning  D. W.
1476-4687 (Electronic)
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Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't --- Old month value: Dec 22
Aspergillus fumigatus is exceptional among microorganisms in being both a primary and opportunistic pathogen as well as a major allergen. Its conidia production is prolific, and so human respiratory tract exposure is almost constant. A. fumigatus is isolated from human habitats and vegetable compost heaps. In immunocompromised individuals, the incidence of invasive infection can be as high as 50% and the mortality rate is often about 50% (ref. 2). The interaction of A. fumigatus and other airborne fungi with the immune system is increasingly linked to severe asthma and sinusitis. Although the burden of invasive disease caused by A. fumigatus is substantial, the basic biology of the organism is mostly obscure. Here we show the complete 29.4-megabase genome sequence of the clinical isolate Af293, which consists of eight chromosomes containing 9,926 predicted genes. Microarray analysis revealed temperature-dependent expression of distinct sets of genes, as well as 700 A. fumigatus genes not present or significantly diverged in the closely related sexual species Neosartorya fischeri, many of which may have roles in the pathogenicity phenotype. The Af293 genome sequence provides an unparalleled resource for the future understanding of this remarkable fungus.
Allergens/*genetics Aspergillus fumigatus/*genetics/immunology/*pathogenicity Gene Expression Profiling Gene Expression Regulation, Fungal Genes, Fungal/genetics *Genome, Fungal *Genomics Hypersensitivity/*microbiology Molecular Sequence Data Oligonucleotide Array Sequence Analysis Sequence Analysis, DNA Temperature Virulence/genetics
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Open Access
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25/01/2008 16:47
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20/08/2019 12:47
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