Acute and Chronic Altitude-Induced Cognitive Dysfunction in Children and Adolescents

Détails

Ressource 1Télécharger: BIB_172338397DB4.P001.pdf (465.08 [Ko])
Etat: Public
Version: Author's accepted manuscript
Licence: Non spécifiée
ID Serval
serval:BIB_172338397DB4
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Acute and Chronic Altitude-Induced Cognitive Dysfunction in Children and Adolescents
Périodique
The Journal of Pediatrics
Auteur⸱e⸱s
Rimoldi Stefano F., Rexhaj Emrush, Duplain Hervé, Urben Sébastien, Billieux Joël, Allemann Yves, Romero Catherine, Ayaviri Alejandro, Salinas Carlos, Villena Mercedes, Scherrer Urs, Sartori Claudio
ISSN
0022-3476
ISSN-L
0022-3476
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
169
Pages
238-243
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
OBJECTIVE: To assess whether exposure to high altitude induces cognitive dysfunction in young healthy European children and adolescents during acute, short-term exposure to an altitude of 3450 m and in an age-matched European population permanently living at this altitude.
STUDY DESIGN: We tested executive function (inhibition, shifting, and working memory), memory (verbal, short-term visuospatial, and verbal episodic memory), and speed processing ability in: (1) 48 healthy nonacclimatized European children and adolescents, 24 hours after arrival at high altitude and 3 months after return to low altitude; (2) 21 matched European subjects permanently living at high altitude; and (3) a matched control group tested twice at low altitude.
RESULTS: Short-term hypoxia significantly impaired all but 2 (visuospatial memory and processing speed) of the neuropsychological abilities that were tested. These impairments were even more severe in the children permanently living at high altitude. Three months after return to low altitude, the neuropsychological performances significantly improved and were comparable with those observed in the control group tested only at low altitude.
CONCLUSIONS: Acute short-term exposure to an altitude at which major tourist destinations are located induces marked executive and memory deficits in healthy children. These deficits are equally marked or more severe in children permanently living at high altitude and are expected to impair their learning abilities.
Mots-clé
Acute Disease, Adolescent, Altitude, Altitude Sickness/complications, Anoxia/complications, Child, Chronic Disease, Cognition/physiology, Cognition Disorders/diagnosis, Cognition Disorders/etiology, Female, Humans, Male, Memory Disorders, Neuropsychological Tests
Pubmed
Web of science
Open Access
Oui
Création de la notice
26/01/2016 12:14
Dernière modification de la notice
21/11/2022 9:23
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