Acute and Chronic Altitude-Induced Cognitive Dysfunction in Children and Adolescents

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Version: Author's accepted manuscript
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Serval ID
serval:BIB_172338397DB4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Acute and Chronic Altitude-Induced Cognitive Dysfunction in Children and Adolescents
Journal
The Journal of Pediatrics
Author(s)
Rimoldi Stefano F., Rexhaj Emrush, Duplain Hervé, Urben Sébastien, Billieux Joël, Allemann Yves, Romero Catherine, Ayaviri Alejandro, Salinas Carlos, Villena Mercedes, Scherrer Urs, Sartori Claudio
ISSN
0022-3476
ISSN-L
0022-3476
Publication state
Published
Issued date
2016
Peer-reviewed
Oui
Volume
169
Pages
238-243
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
OBJECTIVE: To assess whether exposure to high altitude induces cognitive dysfunction in young healthy European children and adolescents during acute, short-term exposure to an altitude of 3450 m and in an age-matched European population permanently living at this altitude.
STUDY DESIGN: We tested executive function (inhibition, shifting, and working memory), memory (verbal, short-term visuospatial, and verbal episodic memory), and speed processing ability in: (1) 48 healthy nonacclimatized European children and adolescents, 24 hours after arrival at high altitude and 3 months after return to low altitude; (2) 21 matched European subjects permanently living at high altitude; and (3) a matched control group tested twice at low altitude.
RESULTS: Short-term hypoxia significantly impaired all but 2 (visuospatial memory and processing speed) of the neuropsychological abilities that were tested. These impairments were even more severe in the children permanently living at high altitude. Three months after return to low altitude, the neuropsychological performances significantly improved and were comparable with those observed in the control group tested only at low altitude.
CONCLUSIONS: Acute short-term exposure to an altitude at which major tourist destinations are located induces marked executive and memory deficits in healthy children. These deficits are equally marked or more severe in children permanently living at high altitude and are expected to impair their learning abilities.
Keywords
Acute Disease, Adolescent, Altitude, Altitude Sickness/complications, Anoxia/complications, Child, Chronic Disease, Cognition/physiology, Cognition Disorders/diagnosis, Cognition Disorders/etiology, Female, Humans, Male, Memory Disorders, Neuropsychological Tests
Pubmed
Web of science
Open Access
Yes
Create date
26/01/2016 12:14
Last modification date
25/01/2020 7:17
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