HIV-1 and human genetic variation.

Détails

ID Serval
serval:BIB_16DF9AACD3B9
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
HIV-1 and human genetic variation.
Périodique
Nature reviews. Genetics
Auteur(s)
McLaren P.J., Fellay J.
ISSN
1471-0064 (Electronic)
ISSN-L
1471-0056
Statut éditorial
In Press
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: aheadofprint
Résumé
Over the past four decades, research on the natural history of HIV infection has described how HIV wreaks havoc on human immunity and causes AIDS. HIV host genomic research, which aims to understand how human genetic variation affects our response to HIV infection, has progressed from early candidate gene studies to recent multi-omic efforts, benefiting from spectacular advances in sequencing technology and data science. In addition to invading cells and co-opting the host machinery for replication, HIV also stably integrates into our own genome. The study of the complex interactions between the human and retroviral genomes has improved our understanding of pathogenic mechanisms and suggested novel preventive and therapeutic approaches against HIV infection.
Pubmed
Web of science
Open Access
Oui
Création de la notice
06/07/2021 12:46
Dernière modification de la notice
10/07/2021 6:33
Données d'usage